The Department of Investigative Medicine provides ample opportunities for student and residents to participate with faculty in research and scholarly activities. We offer experiences that enable discovery and promote creativity. As a department, we are committed to pursuing inquiry, disseminating knowledge, and fostering critical thinking that encourages lifelong learning.
Research and Scholarly Activity, 2019-23
Recent Publications
Chen H., Bai Y., Kobayashi M., Xiao S., Barajas S., Cai W., Chen S., Miao J., Meke F.N., Yao C., Yang Y., Strube K., Satchivi O., Sun J., Ronnstrand L., Croop J.M., Boswell H.S., Jia Y., Liu H., Li L.S., Altman J.K., Eklund E.A., Sukhanova M., Ji P., Tong W., Band H., Huang D.T., Platanias L.C., Zhang Z.Y., Liu Y. PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation Molecular Cancer Research. 2024;22:94-103.
Majeed S.T., Jondle C.N. Bringing Balance: Immune Interactions Regulating Murine Gammaherpesvirus 68 Latency Current Clinical Microbiology Reports. 2024;11:1-11.
Abe J.I., Imanishi M., Li S., Zhang A., Ko K.A., Samanthapudi V.S.K., Lee L.L., Bojorges A.P., Gi Y.J., Hobbs B.P., Deswal A., Herrmann J., Lin S.H., Chini E.N., Shen Y.H., Schadler K.L., Nguyen T.H.M., Gupte A.A., Reyes-Gibby C., Yeung S.C.J., Abe R.J., Olmsted-Davis E.A., Krishnan S., Dantzer R., Palaskas N.L., Cooke J.P., Pownall H.J., Yoshimoto M., Fujiwara K., Hamilton D.J., Burks J.K., Wang G., Le N.T., Kotla S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis Circulation Research. 2023;133:25-44.
Balaj A.R., Kaku H. Newfound physiological function of FAIM protein offers hope of novel disease-modifying therapy for Alzheimer's disease Neural Regeneration Research. 2023;18(12):2677-2679.
Chen H., Bai Y., Kobayashi M., Xiao S., Cai W., Barajas S., Chen S., Miao J., Meke F.N., Vemula S., Ropa J.P., Croop J.M., Boswell H.S., Wan J., Jia Y., Liu H., Li L.S., Altman J.K., Eklund E.A., Ji P., Tong W., Band H., Huang D.T., Platanias L.C., Zhang Z.Y., Liu Y. PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371 Blood. 2023;141:244-259.
Gutknecht M.F., Holodick N.E., Rothstein T.L. B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells iScience. 2023;26
Jain A., Casanova D., Padilla A.V., Paniagua Bojorges A., Kotla S., Ko K.A., Samanthapudi V.S.K., Chau K., Nguyen M.T.H., Wen J., Hernandez Gonzalez S.L., Rodgers S.P., Olmsted-Davis E.A., Hamilton D.J., Reyes-Gibby C., Yeung S.C.J., Cooke J.P., Herrmann J., Chini E.N., Xu X., Yusuf S.W., Yoshimoto M., Lorenzi P.L., Hobbs B., Krishnan S., Koutroumpakis E., Palaskas N.L., Wang G., Deswal A., Lin S.H., Abe J.I., Le N.T. Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights Frontiers in Cardiovascular Medicine. 2023;10
Kobayashi M., Wei H., Yamanashi T., Azevedo Portilho N., Cornelius S., Valiente N., Nishida C., Cheng H., Latorre A., Zheng W.J., Kang J., Seita J., Shih D.J., Wu J.Q., Yoshimoto M. HSC-independent definitive hematopoiesis persists into adult life Cell Reports. 2023;42(3)
Kobayashi M., Yoshimoto M. Multiple waves of fetal-derived immune cells constitute adult immune system Immunological Reviews. 2023;315(1):11-30.
Lin Y., Banno K., Gil C.H., Myslinski J., Hato T., Shelley W.C., Gao H., Xuei X., Liu Y., Basile D.P., Yoshimoto M., Prasain N., Tarnawsky S.P., Adams R.H., Naruse K., Yoshida J., Murphy M.P., Horie K., Yoder M.C. Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans JCI Insight. 2023;8(5)
Ray M.E., Rothstein T.L. Human VH4-34 antibodies derived from B1 cells are more frequently autoreactive than VH4-34 antibodies derived from memory cells Frontiers in Immunology. 2023;14
Webster S.E., Tsuji N.L., Clemente M.J., Holodick N.E. Age-related changes in antigen-specific natural antibodies are influenced by sex Frontiers in Immunology. 2023;13
Banerjee P., Olmsted-Davis E.A., Deswal A., Nguyen M.T., Koutroumpakis E., Palaskas N.L., Lin S.H., Kotla S., Reyes-Gibby C., Yeung S.C.J., Yusuf S.W., Yoshimoto M., Kobayashi M., Yu B., Schadler K., Herrmann J., Cooke J.P., Jain A., Chini E., Le N.T., Abe J.I. Cancer treatment-induced NAD<sup>+</sup> depletion in premature senescence and late cardiovascular complications Journal of Cardiovascular Aging. 2022;2
Gutknecht M.F., Kaku H., Rothstein T.L. Microparticle immunocapture assay for quantitation of protein multimer amount and size Cell Reports Methods. 2022;2
Husain-Krautter S., Lee J., Vos D., Gallego J.A., Malhotra A.K., Rothstein T.L. Skewing of the antibody repertoire in cerebrospinal fluid B cells from healthy controls and patients with schizophrenia Behavioural Brain Research. 2022;422
Imanishi M., Cheng H., Kotla S., Deswal A., Le N.T., Chini E., Ko K.A., Samanthapudi V.S.K., Lee L.L., Herrmann J., Xu X., Reyes-Gibby C., Yeung S.C.J., Schadler K.L., Yusuf S.W., Liao Z., Nurieva R., Amir E.a.D., Burks J.K., Palaskas N.L., Cooke J.P., Lin S.H., Kobayashi M., Yoshimoto M., Abe J.I. Radiation therapy induces immunosenescence mediated by p90RSK Frontiers in Cardiovascular Medicine. 2022;9
Jondle C.N., Sylvester P.A., Schmalzriedt D.L., Njoya K., Tarakanova V.L. The Antagonism between the Murine Gammaherpesvirus Protein Kinase and Global Interferon Regulatory Factor 1 Expression Shapes the Establishment of Chronic Infection Journal of Virology. 2022;96
Jondle C.N., Tarakanova V.L. T Cell-Intrinsic Interleukin 17 Receptor A Signaling Supports the Establishment of Chronic Murine Gammaherpesvirus 68 Infection Journal of Virology. 2022;96
Kadouh N.K., Lang S., Shamoun M., Scott E.L., Singh S.A., Smith M.A. Mexiletine: An adjuvant option for refractory pain in patients with sickle cell disease and comorbid autism spectrum disorder Pediatric Blood and Cancer. 2022;69
Kaku H., Balaj A.R., Rothstein T.L. Small Heat Shock Proteins Collaborate with FAIM to Prevent Accumulation of Misfolded Protein Aggregates International Journal of Molecular Sciences. 2022;23(19)
Rodriguez-Zhurbenko N., Quach T.D., Rothstein T.L., Hernandez A.M. Human B-1 cells are important contributors to the naturally-occurring IgM pool against the tumor-associated ganglioside Neu5GcGM3 Frontiers in Immunology. 2022;13
Srikakulapu P., Pattarabanjird T., Upadhye A., Bontha S.V., Osinski V., Marshall M.A., Garmey J., Deroissart J., Prohaska T.A., Witztum J.L., Binder C.J., Holodick N.E., Rothstein T.L., McNamara C.A. B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis Frontiers in Immunology. 2022;13
Sylvester P.A., Jondle C.N., Schmalzriedt D.L., Dittel B.N., Tarakanova V.L. T Cell-Specific STAT1 Expression Promotes Lytic Replication and Supports the Establishment of Gammaherpesvirus Latent Reservoir in Splenic B Cells mBio. 2022;13
Webster S.E., Ryali B., Clemente M.J., Tsuji N.L., Holodick N.E. Sex Influences Age-Related Changes in Natural Antibodies and CD5<sup>+</sup> B-1 Cells Journal of Immunology. 2022;208:1755-1771.
Yoshimoto M., Kosters A., Cornelius S., Valiente N., Cheng H., Latorre A., Nishida C., Ghosn E.E.B., Kobayashi M. Mast Cell Repopulating Ability Is Lost During the Transition From Pre-HSC to FL HSC Frontiers in Immunology. 2022;13
Yu L., Myers G., Schneider E., Wang Y., Mathews R., Lim K.C., Siemieniak D., Tang V., Ginsburg D., Balbin-Cuesta G., Singh S.A., Phuwakanjana P., Jearawiriyapaisarn N., Khoriaty R., Engel J.D. Identification of novel γ-globin inducers among all potential erythroid druggable targets Blood Advances. 2022;6:3280-3285.
Ding J., Cardoso A.A., Yoshimoto M., Kobayashi M. The Earliest T-Precursors in the Mouse Embryo Are Susceptible to Leukemic Transformation Frontiers in Cell and Developmental Biology. 2021;9
Irwin M., Gunther W., Keefer P., Saul D.A., Singh S.A., Wright J., Smith M.A. Buprenorphine for Chronic Pain in a Pediatric Patient With Sickle-Cell Disease Journal of Pain and Symptom Management. 2021;62:1086-1091.
Johnson K.E., Sylvester P.A., Jondle C.N., Aurubin C.A., Tarakanovaa V.L. Interferon Regulatory Factor 3 Supports the Establishment of Chronic Gammaherpesvirus Infection in a Route- And Dose-Dependent Manner Journal of Virology. 2021;95(9)
Jondle C.N., Johnson K.E., Aurubin C., Sylvester P., Xin G., Cui W., Huppler A.R., Tarakanova V.L. Gammaherpesvirus usurps host il-17 signaling to support the establishment of chronic infection mBio. 2021;12(2)
Jondle C.N., Johnson K.E., Mboko W.P., Tarakanova V.L. T cell-intrinsic interferon regulatory factor 1 expression suppresses differentiation of CD4<sup>+</sup> T cell populations that support chronic gammaherpesvirus infection Journal of Virology. 2021;95(20)
Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L. Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species Frontiers in Molecular Neuroscience. 2021;14
Khan N., Hu Y., Lowell C.A., Rothstein T.L. Signal integration by translocation and phosphorylation of PKCd in the B Cell alternate pathway Journal of Immunology. 2021;207(9):2288-2296.
Khan N., Rothstein T.L. The Alternate Pathway for BCR Signaling Induced by IL-4 Requires Lyn Tyrosine Kinase Journal of Molecular Biology. 2021;433(1)
Lewis K., Yoshimoto M., Takebe T. Fetal liver hematopoiesis: from development to delivery Stem Cell Research and Therapy. 2021;12(1)
Ludlow A., George N., Glassford M., Udenberg K., Hannibal M.C., Schwalm C., Scott K., Rothstein T.L., Singh S.A. The Use of B-Cell Polysome Profiling to Validate Novel RPL5 (uL18) and RPL26 (uL24) Variants in Diamond-Blackfan Anemia Journal of Pediatric Hematology/Oncology. 2021;43:e336-e340.
Portilho N.A., Scarfo R., Bertesago E., Ismailoglu I., Kyba M., Kobayashi M., Ditadi A., Yoshimoto M. B1 lymphocytes develop independently of Notch signaling during mouse embryonic development Development (Cambridge). 2021;148(15)
Sylvester P.A., Jondle C.N., Stoltz K.P., Lanham J., Dittel B.N., Tarakanova V.L. Conserved gammaherpesvirus protein kinase counters the antiviral effects of myeloid cell-specific stat1 expression to promote the establishment of splenic b cell latency Journal of Virology. 2021;95(17)
Wang Y., Yu L., Engel J.D., Singh S.A. Epigenetic activities in erythroid cell gene regulation Seminars in Hematology. 2021;58:4-9.
Yoshimoto M., Ditadi A. The people behind the papers - Nathalia Azevedo Portilho, Rebecca Scarfò, Andrea Ditadi and Momoko Yoshimoto Development (Cambridge). 2021;148(15)
Yu H., Gao R., Chen S., Liu X., Wang Q., Cai W., Vemula S., Fahey A.C., Henley D., Kobayashi M., Liu S.Z., Qian Z., Kapur R., Broxmeyer H.E., Gao Z., Xi R., Liu Y. Bmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells Stem Cell Reviews and Reports. 2021;17:2304-2313.
Yu L., Lemay P., Ludlow A., Guyot M.C., Jones M., Mohamed F.F., Saroya G.A., Panaretos C., Schneider E., Wang Y., Myers G., Khoriaty R., Li Q., Franceschi R., Engel J.D., Kaartinen V., Rothstein T.L., Justice M.J., Kibar Z., Singh S.A. A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia Blood Advances. 2021;5:4167-4178.
Yu L., Myers G., Ku C.J., Schneider E., Wang Y., Singh S.A., Jearawiriyapaisarn N., White A., Moriguchi T., Khoriaty R., Yamamoto M., Rosenfeld M.G., Pedron J., Bushweller J.H., Lim K.C., Engel J.D. An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation Blood. 2021;138:1691-1704.
Chen S., Wang Q., Yu H., Capitano M.L., Vemula S., Nabinger S.C., Gao R., Yao C., Kobayashi M., Geng Z., Fahey A., Henley D., Liu S.Z., Barajas S., Cai W., Wolf E.R., Ramdas B., Cai Z., Gao H., Luo N., Sun Y., Wong T.N., Link D.C., Liu Y., Boswell H.S., Mayo L.D., Huang G., Kapur R., Yoder M.C., Broxmeyer H.E., Gao Z., Liu Y. Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2) Nature Communications. 2020;11(1)
Johnson K.E., Aurubin C.A., Jondle C.N., Lange P.T., Tarakanova V.L. Interferon regulatory factor 7 attenuates chronic gammaherpesvirus infection Journal of Virology. 2020;94(24)
Johnson K.E., Lange P.T., Jondle C.N., Volberding P.J., Lorenz U.M., Cui W., Dittel B.N., Tarakanova V.L. B cell-intrinsic SHP1 expression promotes the gammaherpesvirus-driven germinal center response and the establishment of chronic infection Journal of Virology. 2020;94(1)
Jondle C.N., Johnson K.E., Uitenbroek A.A., Sylvester P.A., Nguyen C., Cui W., Tarakanova V.L. B cell-intrinsic expression of interferon regulatory factor 1 supports chronic murine gammaherpesvirus 68 infection Journal of Virology. 2020;94(13)
Jondle C.N., Tarakanova V.L. Innate immunity and alpha/gammaherpesviruses: first impressions last a lifetime Current Opinion in Virology. 2020;44:81-89.
Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L. FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis Frontiers in Neuroscience. 2020;14
Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L. FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis Frontiers in Neuroscience. 2020;14
Kaku H., Rothstein T.L. FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates Frontiers in Molecular Biosciences. 2020;7
Kobayashi M., Lin Y., Mishra A., Shelly C., Gao R., Reeh C.W., Wang P.Z., Xi R., Liu Y., Wenzel P., Ghosn E., Liu Y., Yoshimoto M. Bmi1 maintains the self-renewal property of innate-like B lymphocytes Journal of Immunology. 2020;204(12):3262-3272.
Kobayashi M., Yoshimoto M. A Modified Semisolid Clonal Culture for Identification of B-1 and B-2 Progenitor Colony Forming Ability of Mouse Embryonic Hemogenic Endothelial Cells Bio-protocol. 2020;10(9)
Singh S.A., Bakshi N., Mahajan P., Morris C.R. What is the future of patient-reported outcomes in sickle-cell disease? Expert Review of Hematology. 2020;13:1165-1173.
Tsuji N., Rothstein T.L., Holodick N.E. Antigen Receptor Specificity and Cell Location Influence the Diversification and Selection of the B-1a Cell Pool with Age Journal of immunology (Baltimore, Md. : 1950). 2020;205:741-759.
Yoshimoto M. The ontogeny of murine B-1a cells International Journal of Hematology. 2020;111(5):622-627.
Azevedo Portilho N., Kobayashi M., Yoshimoto M. What do the lineage tracing studies tell us? Consideration for hematopoietic stem cell origin, dynamics, and leukemia-initiating cells International Journal of Hematology. 2019;109(1):35-40.
Chen S., Wang Q., Yu H., Capitano M.L., Vemula S., Nabinger S.C., Gao R., Yao C., Kobayashi M., Geng Z., Fahey A., Henley D., Liu S.Z., Barajas S., Cai W., Wolf E.R., Ramdas B., Cai Z., Gao H., Luo N., Sun Y., Wong T.N., Link D.C., Liu Y., Boswell H.S., Mayo L.D., Huang G., Kapur R., Yoder M.C., Broxmeyer H.E., Gao Z., Liu Y. Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway Nature Communications. 2019;10(1)
Darrah E., Jondle C., Johnson K., Xin G., Lange P., Cui W., Olteanu H., Tarakanova V. Conserved gammaherpesvirus protein kinase selectively promotes irrelevant B cell responses Journal of Virology. 2019;93(8)
Ghosn E., Dorshkind K., Herzenberg L.A., Holodick N., Kantor A., Montecino-Rodriguez E., Rothstein T.L., Silverman G., Yang Y., Yoder M.C., Yoshimoto M. B1 B cell progenitors Science. 2019;364:248.
Ghosn E., Yoshimoto M., Nakauchi H., Weissman I.L., Herzenberg L.A. Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes Development (Cambridge). 2019;146(15)
Guo B., Ludlow A.V., Brightwell A.S., Rothstein T.L. Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice Cellular Immunology. 2019;346
Kobayashi M., Tarnawsky S.P., Wei H., Mishra A., Azevedo Portilho N., Wenzel P., Davis B., Wu J., Hadland B., Yoshimoto M. Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo Stem Cell Reports. 2019;13(1):21-30.
Lange P.T., Jondle C.N., Darrah E.J., Johnson K.E., Tarakanovaa V.L. LXR alpha restricts gammaherpesvirus reactivation from latently infected peritoneal cells Journal of Virology. 2019;93(6)
Lin Y., Kobayashi M., Azevedo Portilho N., Mishra A., Gao H., Liu Y., Wenzel P., Davis B., Yoder M.C., Yoshimoto M. Long-Term Engraftment of ESC-Derived B-1 Progenitor Cells Supports HSC-Independent Lymphopoiesis Stem Cell Reports. 2019;12(3):572-583.
Nabinger S., Chen S., Gao R., Yao C., Kobayashi M., Vemula S., Fahey A., Wang C., Daniels C., Boswell H., Sandusky G., Mayo L., Kapur R., Liu Y. Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development Leukemia. 2019;33(6):1535-1539.
Rodriguez-Zhurbenko N., Quach T.D., Hopkins T.J., Rothstein T.L., Hernandez A.M. Human B-1 cells and B-1 cell antibodies change with advancing age Frontiers in Immunology. 2019;10(MAR)
Stoltz K., Jondle C., Pulakanti K., Sylvester P., Urrutia R., Rao S., Tarakanova V. Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus Virology. 2019;526:52-60.
Upadhye A., Srikakulapu P., Gonen A., Hendrikx S., Perry H.M., Nguyen A., McSkimming C., Marshall M.A., Garmey J.C., Taylor A.M., Bender T.P., Tsimikas S., Holodick N.E., Rothstein T.L., Witztum J.L., McNamara C.A. Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis Circulation research. 2019;125:e55-e70.
Yoshimoto M. B-1 progenitor acute lymphoid leukemia Blood. 2019;133(24):2557-2558.
Zaffiri L., Shah R.J., Stearman R.S., Rothhaar K., Emtiazjoo A.M., Yoshimoto M., Fisher A.J., Mickler E.A., Gartenhaus M.D., Cohort L.T.O.G., Diamond J.M., Geraci M.W., Christie J.D., Wilkes D.S. Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation Transplant Immunology. 2019;56
Aziz M., Ode Y., Zhou M., Ochani M., Holodick N., Rothstein T., Wang P. B-1a cells protect mice from sepsis-induced acute lung injury Molecular Medicine. 2018;24
Chauhan A., Sun Y., Sukumaran P., Quenum Zangbede F.O., Jondle C.N., Sharma A., Evans D.L., Chauhan P., Szlabick R.E., Aaland M.O., Birnbaumer L., Sharma J., Singh B.B., Mishra B.B. M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry iScience. 2018;8:85-102.
Chen S., Gao R., Yao C., Kobayashi M., Liu S., Yoder M., Broxmeyer H., Kapur R., Boswell H., Mayo L., Liu Y. Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53 Leukemia. 2018;32(3):850-854.
Gallego J., Blanco E., Husain-Krautter S., Madeline Fagen E., Moreno-Merino P., del Ojo-Jiménez J., Ahmed A., Rothstein T., Lencz T., Malhotra A. Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis Schizophrenia Research. 2018;202:64-71.
Hadland B., Yoshimoto M. Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells Experimental Hematology. 2018;60:1-9.
Hato T., Zollman A., Plotkin Z., El-Achkar T.M., Maier B.F., Louise Pay S., Dube S., Cabral P., Yoshimoto M., McClintick J., Dagher P.C. Endotoxin preconditioning reprograms S1 tubules and macrophages to protect the kidney Journal of the American Society of Nephrology. 2018;29(1):104-117.
Huang W., Quach T.D., Dascalu C., Liu Z., Leung T., Byrne-Steele M., Pan W., Yang Q., Han J., Lesser M., Rothstein T.L., Furie R., Mackay M., Aranow C., Davidson A. Belimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients JCI insight. 2018;3(17)
Jondle C., Gupta K., Mishra B., Sharma J. Klebsiella pneumoniae infection of murine neutrophils impairs their efferocytic clearance by modulating cell death machinery PLoS Pathogens. 2018;14(10)
Singh S.A., Sarangi S., Appiah-Kubi A., Hsu P., Smith W., Gallagher P.G., Glader B., Chui D.H.K. Hb Adana (HBA2 or HBA1: c.179G > A) and alpha thalassemia: Genotype–phenotype correlation Pediatric Blood and Cancer. 2018;65
Spidale N.A., Sylvia K., Narayan K., Miu B., Frascoli M., Melichar H.J., Zhihao W., Kisielow J., Palin A., Serwold T., Love P., Kobayashi M., Yoshimoto M., Jain N., Kang J. Interleukin-17-Producing γδ T Cells Originate from SOX13<sup>+</sup> Progenitors that Are Independent of γδTCR Signaling Immunity. 2018;49(5):857-872.e5.
Ward S.E., O’Sullivan J.M., Drakeford C., Aguila S., Jondle C.N., Sharma J., Fallon P.G., Brophy T.M., Preston R.J.S., Smyth P., Sheils O., Chion A., O’Donnell J.S. A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance Blood. 2018;131(8):911-916.
Aziz M., Holodick N., Rothstein T., Wang P. B-1a cells protect mice from sepsis: Critical role of creb Journal of Immunology. 2017;199(2):750-760.
Chen S., Gao R., Kobayashi M., Yu H., Yao C., Kapur R., Yoder M., Liu Y. Pharmacological inhibition of AKT activity in human CD34<sup>+</sup> cells enhances their ability to engraft immunodeficient mice Experimental Hematology. 2017;45:74-84.
Hadland B.K., Varnum-Finney B., Mandal P.K., Rossi D.J., Poulos M.G., Butler J.M., Rafii S., Yoder M.C., Yoshimoto M., Bernstein I.D. A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells Stem Cell Reports. 2017;8(6):1563-1572.
Hernandez A., Holodick N. Editorial: Natural antibodies in health and disease Frontiers in Immunology. 2017;8(DEC)
Holodick N., Rodríguez-Zhurbenko N., Hernández A. Defining natural antibodies Frontiers in Immunology. 2017;8(JUL)
Kaku H., Holodick N., Tumang J., Rothstein T. CD25<sup>+</sup> B-1a cells express Aicda Frontiers in Immunology. 2017;8
Kobayashi M., Bai Y., Chen S., Gao R., Yao C., Cai W., Cardoso A.A., Croop J., Zhang Z.Y., Liu Y. Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia Leukemia. 2017;31(3):751-754.
Kobayashi M., Chen S., Bai Y., Yao C., Gao R., Sun X., Mu C., Twiggs T., Yu Z., Boswell H., Yoder M., Kapur R., Mulloy J., Zhang Z., Liu Y. Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia Leukemia. 2017;31(6):1453-1457.
Kobayashi M., Nabinger S., Bai Y., Yoshimoto M., Gao R., Chen S., Yao C., Dong Y., Zhang L., Rodriguez S., Yashiro-Ohtani Y., Pear W., Carlesso N., Yoder M., Kapur R., Kaplan M., Daniel Lacorazza H., Zhang Z., Liu Y. Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors Stem Cells. 2017;35(4):1053-1064.
Martínez D., Pupo A., Cabrera L., Raymond J., Holodick N.E., Hernández A.M. B-CD8<sup>+</sup> T cell interactions in the anti-idiotypic response against a self-antibody Journal of Immunology Research. 2017;2017
Sharma A., Simonson T.J., Jondle C.N., Mishra B.B., Sharma J. Mincle-mediated neutrophil extracellular trap formation by regulation of autophagy Journal of Infectious Diseases. 2017;215(7):1040-1048.
Tarnawsky S.P., Yoshimoto M., Deng L., Chan R.J., Yoder M.C. Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice Developmental Dynamics. 2017;246(12):1001-1014.
Yao C., Kobayashi M., Chen S., Nabinger S.C., Gao R., Liu S.Z., Asai T., Liu Y. Necdin modulates leukemia-initiating cell quiescence and chemotherapy response Oncotarget. 2017;8(50):87607-87622.
Yoshimoto M., Yoder M.C. Developmental Biology of Stem Cells Fetal and Neonatal Physiology, 2-Volume Set. 2017:1094-1104.e2.
Cui X., Zhang L., Magli A.R., Catera R., Yan X.J., Griffin D.O., Rothstein T.L., Barrientos J., Kolitz J.E., Allen S.L., Rai K.R., Chiorazzi N., Chu C.C. Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability Leukemia. 2016;30(1):74-85.
Dulmovits B.M., Appiah-Kubi A.O., Papoin J., Hale J., He M., Al-Abed Y., Didier S., Gould M., Husain-Krautter S., Singh S.A., Chan K.W.H., Vlachos A., Allen S.L., Taylor N., Marambaud P., An X., Gallagher P.G., Mohandas N., Lipton J.M., Liu J.M., Blanc L. Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors Blood. 2016;127:1481-1492.
Ghosh J., Kobayashi M., Ramdas B., Chatterjee A., Ma P., Mali R.S., Carlesso N., Liu Y., Plas D.R., Chan R.J., Kapur R. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance Journal of Clinical Investigation. 2016;126(7):2621-2625.
Guo B., Rothstein T. RasGRP1 is an essential signaling molecule for development of B1a cells with autoantigen receptors Journal of Immunology. 2016;196:2583-2590.
Guo B., Zhang L., Chiorazzi N., Rothstein T.L. IL-4 rescues surface IgM expression in chronic lymphocytic leukemia Blood. 2016;128:553-562.
Holodick N., Vizconde T., Hopkins T., Rothstein T. Age-related decline in natural igm function: Diversification and selection of the B-1a cell pool with age Journal of Immunology. 2016;196(10):4348-4357.
Holodick N.E., Zeumer L., Rothstein T.L., Morel L. Expansion of B-1a cells with germline heavy chain sequence in lupus mice Frontiers in Immunology. 2016;7(MAR)
Jondle C.N., Sharma A., Simonson T.J., Larson B., Mishra B.B., Sharma J. Macrophage galactose-type lectin-1 deficiency is associated with increased neutrophilia and hyperinflammation in gram-negative pneumonia Journal of Immunology. 2016;196(7):3088-3096.
Kramer J.M., Holodick N.E., Vizconde T.C., Raman I., Yan M., Li Q.Z., Gaile D.P., Rothstein T.L. Analysis of IgM antibody production and repertoire in a mouse model of Sjögren’s syndrome Journal of Leukocyte Biology. 2016;99(2):321-331.
Olofsson P.S., Steinberg B., Sobbi R., Cox M.A., Ahmed M.N., Oswald M., Szekeres F., Hanes W.M., Introini A., Liu S.F., Holodick N.E., Rothstein T.L., Lövdahl C., Chavan S.S., Yang H., Pavlov V.A., Broliden K., Andersson U., Diamond B., Miller E.J., Arner A., Gregersen P.K., Backx P.H., Mak T.W., Tracey K.J. Blood pressure regulation by CD4<sup>+</sup> lymphocytes expressing choline acetyltransferase Nature Biotechnology. 2016;34(10):1066-1071.
Quach T., Rodriguez-Zhurbenko N., Hopkins T., Guo X., Hernandez A., Li W., Rothstein T. Distinctions among circulating antibody-secreting cell populations, including B-1 cells, in human adult peripheral blood Journal of Immunology. 2016;196(3):1060-1069.
Quách T.D., Hopkins T.J., Holodick N.E., Vuyyuru R., Manser T., Bayer R.L., Rothstein T.L. Human B-1 and B-2 B cells develop from Lin<sup>-</sup>CD34<sup>+</sup>CD38<sup>lo</sup> stem cells Journal of Immunology. 2016;197(10):3950-3958.
Rothstein T. Natural antibodies as rheostats for susceptibility to chronic diseases in the aged Frontiers in Immunology. 2016;7(APR)
Rothstein T., Holodick N. Activation of B-1 Cells Encyclopedia of Immunobiology. 2016;3:237-243.
Sharma A., Kiripolsky J., Klimatcheva E., Howell A., Fereidouni F., Levenson R., Rothstein T.L., Kramer J.M. Early BAFF receptor blockade mitigates murine Sjögren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction Clinical Immunology. 2016;164:85-94.
Wood J.C., Cohen A.R., Pressel S.L., Aygun B., Imran H., Luchtman-Jones L., Thompson A.A., Fuh B., Schultz W.H., Davis B.R., Ware R.E., George A., Mueller B.U., Heeney M.M., Kalfa T.A., Nelson S., Clark Brown R., Gee B., Kwiatkowski J.L., Smith- Whitley K., Odame I., Webb J., Yang E., Lee M.T., Piccone C., Jackson S.M., Singh S., Nottage K., Hankins J.S., Miller S.T., Hilliard L., Alvarez O., Rhodes M., Rogers Z.R., Sarnaik S.A., Owen W.C., Gauger C., Roberts C., Rothman J.A. Organ iron accumulation in chronically transfused children with sickle cell anaemia: Baseline results from the TWiTCH trial British Journal of Haematology. 2016;172:122-130.
Yoon J., Wang H., Kim Y.C., Yoshimoto M., Abbasi S., Morse H.C. Plasma cell alloantigen ENPP1 is expressed by a subset of human B cells with potential regulatory functions Immunology and Cell Biology. 2016;94(8):719-728.
Aziz M., Holodick N.E., Rothstein T.L., Wang P. The role of B-1 cells in inflammation Immunologic Research. 2015;63(1-3):153-166.
Engelbertsen D., Vallejo J., Dan Quách T., Fredrikson G.N., Alm R., Hedblad B., Björkbacka H., Rothstein T.L., Nilsson J., Bengtsson E. Low levels of IgM antibodies against an advanced glycation endproduct-modified apolipoprotein B100 peptide predict cardiovascular events in nondiabetic subjects Journal of Immunology. 2015;195(7):3020-3025.
Gao R., Chen S., Kobayashi M., Yu H., Zhang Y., Wan Y., Young S.K., Soltis A., Yu M., Vemula S., Fraenkel E., Cantor A., Antipin Y., Xu Y., Yoder M.C., Wek R.C., Ellis S.R., Kapur R., Zhu X., Liu Y. Bmi1 promotes erythroid development through regulating ribosome biogenesis Stem Cells. 2015;33(3):925-938.
Hato T., Winfree S., Kalakeche R., Dube S., Kumar R., Yoshimoto M., Plotkin Z., Dagher P.C. The macrophage mediates the renoprotective effects of endotoxin preconditioning Journal of the American Society of Nephrology. 2015;26(6):1347-1362.
Holodick N., Rothstein T. B cells in the aging immune system: Time to consider B-1 cells Annals of the New York Academy of Sciences. 2015;1362(1):176-187.
Husain-Krautter S., Kramer J.M., Li W., Guo B., Rothstein T.L. The osteopontin transgenic mouse is a new model for Sjögren's syndrome Clinical Immunology. 2015;157:30-42.
Kim H., Prasain N., Vemula S., Ferkowicz M.J., Yoshimoto M., Voytik-Harbin S.L., Yoder M.C. Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices Microvascular Research. 2015;101:72-81.
Rothstein T., Herzenberg L., Holodick N., Ghosn E. B-1 Cell Development and Function Annals of the New York Academy of Sciences. 2015;1362(1):v-vi.
Rothstein T., Quach T. The human counterpart of mouse B-1 cells Annals of the New York Academy of Sciences. 2015;1362(1):143-152.
Yoshimoto M. The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo Annals of the New York Academy of Sciences. 2015;1362(1):16-22.
Yoshimoto M., Koenig J. Stem Cells: Potential Therapy for Neonatal Injury? Clinics in Perinatology. 2015;42(3):597-612.