Assistant Professor, Department of Investigative Medicine
Biosketch
Michael Clemente, MS, SCYM (ASCP) serves as the Flow Cytometry and Imaging Core Senior Manager in the Center for Immunobiology at Western Michigan University Homer Stryker MD School of Medicine. Michael received a bachelor of philosophy from Miami University of Ohio and a bachelor of science in biology from Cleveland State University. He further completed a master of science in biology with a focus in immunology/pathology at Case Western Reserve university. He is board certified by the American Society of Clinical Pathology, Specialist in Cytometry.
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Education and Training
- MS 2007, Biology, Case Western Reserve University
- BS 2003, Biology, Cleveland State University
- BA 1993, Philosophy, Miami University of Ohio
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Publications
Lundgren S., Huuhtanen J., Keränen M., Feng X., Patel B.A., Ryland G.L., Fox L.C., Bravo-Perez C., Clemente M., Kerr C., Walldin G., Dufva O., Zaimoku Y., Tuononen T., Myllymäki M., Ebeling F., Jokinen E., Heinonen M., Kasanen T., Klievink J., Lähteenmäki H., Jaatinen T., Kytölä S., Siitonen S., Dulau-Florea A., Braylan R., Heinäniemi M., Nakao S., Hellström-Lindberg E., Maciejewski J.P., Blombery P., Young N.S., Lähdesmäki H., Mustjoki S. Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8+ T cells with a disease-associated TCR signature Science Translational Medicine. 2025;17(787)
Webster S.E., Les S.M., Deleon N., Heck D.M., Tsuj N.L., Clemente M.J., Jones P., Holodick N.E. Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging Immunity and Ageing. 2025;22
Asosingh K., Bayiyana A., Black M.C., Chakraborty U., Clemente M.J., Graham A.C., Gregory M.D., Hogg K.G., Van Isterdael G., Liu C.C., Martínez L., Petersen C.C., Porat Z., Price K.M., Prickett L.B., Rieger A.M., Roe C.E., Smit E. Best practices for user consultation in flow cytometry shared resource laboratories Cytometry Part A. 2024;105(9):704-712.
Webster S.E., Tsuji N.L., Clemente M.J., Holodick N.E. Age-related changes in antigen-specific natural antibodies are influenced by sex Frontiers in Immunology. 2023;13
Webster S.E., Ryali B., Clemente M.J., Tsuji N.L., Holodick N.E. Sex Influences Age-Related Changes in Natural Antibodies and CD5<sup>+</sup> B-1 Cells Journal of Immunology. 2022;208:1755-1771.
Lundgren S., Keränen M.A.I., Kankainen M., Huuhtanen J., Walldin G., Kerr C.M., Clemente M., Ebeling F., Rajala H., Brück O., Lähdesmäki H., Hannula S., Hannunen T., Ellonen P., Young N.S., Ogawa S., Maciejewski J.P., Hellström-Lindberg E., Mustjoki S. Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia Leukemia. 2021;35(5):1365-1379.
Kerr C.M., Clemente M.J., Chomczynski P.W., Przychodzen B., Nagata Y., Adema V., Visconte V., Lichtin A.E., Mustjoki S., Radivoyevitch T., Sekeres M.A., Maciejewski J.P. Subclonal STAT3 mutations solidify clonal dominance Blood Advances. 2019;3(6):917-921.
Bat T., Abdelhamid O.N., Balasubramanian S.K., Mai A., Radivoyevitch T., Clemente M., Maciejewski J.P. The evolution of paroxysmal nocturnal haemoglobinuria depends on intensity of immunosuppressive therapy British Journal of Haematology. 2018;182(5):730-733.
Clemente M.J., Przychodzen B., Hirsch C.M., Nagata Y., Bat T., Wlodarski M.W., Radivoyevitch T., Makishima H., Maciejewski J.P. Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria Leukemia. 2018;32(11):2507-2511.
Przychodzen B., Makishima H., Sekeres M.A., Balasubramanian S.K., Thota S., Patel B.J., Clemente M., Hirsch C., Dienes B., Maciejewski J.P. Fanconi Anemia germline variants as susceptibility factors in aplastic anemia, MDS and AML Oncotarget. 2018;9(2):2050-2057.
Sanikommu S.R., Clemente M.J., Chomczynski P., Afable M.G., Jerez A., Thota S., Patel B., Hirsch C., Nazha A., Desamito J., Lichtin A., Pohlman B., Sekeres M.A., Radivoyevitch T., Maciejewski J.P. Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL) Leukemia and Lymphoma. 2018;59(2):416-422.
Coppe A., Andersson E.I., Binatti A., Gasparini V.R., Bortoluzzi S., Clemente M., Herling M., Maciejewski J., Mustjoki S., Bortoluzzi S. Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach Leukemia. 2017;31(5):1243-1246.
Hirsch C.M., Przychodzen B.P., Radivoyevitch T., Patel B., Thota S., Clemente M.J., Nagata Y., LaFramboise T., Carraway H.E., Nazha A., Sekeres M.A., Makishima H., Maciejewski J.P. Molecular features of early onset adult myelodysplastic syndrome Haematologica. 2017;102(6):1028-1034.
Hosono N., Makishima H., Mahfouz R., Przychodzen B., Yoshida K., Jerez A., LaFramboise T., Polprasert C., Clemente M.J., Shiraishi Y., Chiba K., Tanaka H., Miyano S., Sanada M., Cui E., Verma A.K., McDevitt M.A., List A.F., Saunthararajah Y., Sekeres M.A., Boultwood J., Ogawa S., Maciejewski J.P. Recurrent genetic defects on chromosome 5q in myeloid neoplasms Oncotarget. 2017;8(4):6483-6495.
Negoro E., Nagata Y., Clemente M.J., Hosono N., Shen W., Nazha A., Yoshizato T., Hirsch C., Przychodzen B., Mahfouz R.Z., Kuzmanovic T., Sekeres M.A., Makishima H., Ogawa S., Maciejewski J.P. Origins of myelodysplastic syndromes after aplastic anemia Blood. 2017;130(17):1953-1957.
Patel B.J., Przychodzen B., Thota S., Radivoyevitch T., Visconte V., Kuzmanovic T., Clemente M., Hirsch C., Morawski A., Souaid R., Saygin C., Nazha A., Demarest B., Laframboise T., Sakaguchi H., Kojima S., Carraway H.E., Ogawa S., Makishima H., Sekeres M.A., Maciejewski J.P. Genomic determinants of chronic myelomonocytic leukemia Leukemia. 2017;31(12):2815-2823.
Andersson E., Kuusanmäki H., Bortoluzzi S., Lagström S., Parsons A., Rajala H., Van Adrichem A., Eldfors S., Olson T., Clemente M.J., Laasonen A., Ellonen P., Heckman C., Loughran T.P., Maciejewski J.P., Mustjoki S. Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia Leukemia. 2016;30(5):1204-1208.
Nazha A., Zarzour A., Al-Issa K., Radivoyevitch T., Carraway H.E., Hirsch C.M., Przychodzen B., Patel B.J., Clemente M., Sanikommu S.R., Kalaycio M., Maciejewski J.P., Sekeres M.A. The complexity of interpreting genomic data in patients with acute myeloid leukemia Blood Cancer Journal. 2016;6(12)
Negoro E., Radivoyevitch T., Polprasert C., Adema V., Hosono N., Makishima H., Przychodzen B., Hirsch C., Clemente M.J., Nazha A., Santini V., McGraw K.L., List A.F., Sole F., Sekeres M.A., Maciejewski J.P. Molecular predictors of response in patients with myeloid neoplasms treated with lenalidomide Leukemia. 2016;30(12):2405-2409.
Bilori B., Thota S., Clemente M.J., Patel B., Jerez A., Afable M., Maciejewski J.P. Tofacitinib as a novel salvage therapy for refractory T-cell large granular lymphocytic leukemia Leukemia. 2015;29(12):2427-2429.
Huang D., Nagata Y., Grossmann V., Radivoyevitch T., Okuno Y., Nagae G., Hosono N., Schnittger S., Sanada M., Przychodzen B., Kon A., Polprasert C., Shen W., Clemente M.J., Phillips J.G., Alpermann T., Yoshida K., Nadarajah N., Sekeres M.A., Oakley K., Nguyen N., Shiraishi Y., Shiozawa Y., Chiba K., Tanaka H., Phillip Koeffler H., Klein H.U., Dugas M., Aburatani H., Miyano S., Haferlach C., Kern W., Haferlach T., Du Y., Ogawa S., Makishima H. BRCC3 mutations in myeloid neoplasms Haematologica. 2015;100(8):1051-1057.
Kurtovic-Kozaric A., Przychodzen B., Singh J., Konarska M.M., Clemente M.J., Otrock Z.K., Nakashima M., Hsi E.D., Yoshida K., Shiraishi Y., Chiba K., Tanaka H., Miyano S., Ogawa S., Boultwood J., Makishima H., Maciejewski J.P., Padgett R.A. PRPF8 defects cause missplicing in myeloid malignancies Leukemia. 2015;29(1):126-136.
Molenaar R.J., Thota S., Nagata Y., Patel B., Clemente M., Przychodzen B., Hirsh C., Viny A.D., Hosano N., Bleeker F.E., Meggendorfer M., Alpermann T., Shiraishi Y., Chiba K., Tanaka H., Van Noorden C.J.F., Radivoyevitch T., Carraway H.E., Makishima H., Miyano S., Sekeres M.A., Ogawa S., Haferlach T., Maciejewski J.P. Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms Leukemia. 2015;29(11):2134-2142.
Patel B., Hirsch C., Clemente M., Sekeres M., Makishima H., Maciejewski J. Genetic and molecular characterization of myelodysplastic syndromes and related myeloid neoplasms International Journal of Hematology. 2015;101(3):213-218.
Polprasert C., Schulze I., Sekeres M.A., Makishima H., Przychodzen B., Hosono N., Singh J., Padgett R.A., Gu X., Phillips J.G., Clemente M., Parker Y., Lindner D., Dienes B., Jankowsky E., Saunthararajah Y., Du Y., Oakley K., Nguyen N., Mukherjee S., Pabst C., Godley L.A., Churpek J.E., Pollyea D.A., Krug U., Berdel W.E., Klein H.U., Dugas M., Shiraishi Y., Chiba K., Tanaka H., Miyano S., Yoshida K., Ogawa S., Müller-Tidow C., Maciejewski J.P. Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms Cancer Cell. 2015;27(5):658-670.
Rajala H.L.M., Olson T., Clemente M.J., Lagström S., Ellonen P., Lundan T., Hamm D.E., Arshi Uz Zaman S., Lopez Marti J.M., Andersson E.I., Jerez A., Porkka K., Maciejewski J.P., Loughran T.P., Mustjoki S. The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia Haematologica. 2015;100(1):91-99.
Yoshizato T., Dumitriu B., Hosokawa K., Makishima H., Yoshida K., Townsley D., Sato-Otsubo A., Sato Y., Liu D., Suzuki H., Wu C.O., Shiraishi Y., Clemente M.J., Kataoka K., Shiozawa Y., Okuno Y., Chiba K., Tanaka H., Nagata Y., Katagiri T., Kon A., Sanada M., Scheinberg P., Miyano S., Maciejewski J.P., Nakao S., Young N.S., Ogawa S. Somatic mutations and clonal hematopoiesis in aplastic anemia New England Journal of Medicine. 2015;373(1):35-47.
Bretschneider I., Clemente M.J., Meisel C., Guerreiro M., Streitz M., Hopfenmüller W., Maciejewski J.P., Wlodarski M.W., Volk H.D. Discrimination of T-cell subsets and T-cell receptor repertoire distribution Immunologic Research. 2014;58(1):20-27.
Jerez A., Clemente M.J., Makishima H. Erratum: STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients (Blood (2013) 122:14 (2453-2459)) Blood. 2014;123(21):3364.
Shen W., Clemente M.J., Hosono N., Yoshida K., Przychodzen B., Yoshizato T., Shiraishi Y., Miyano S., Ogawa S., Maciejewski J.P., Makishima H. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria Journal of Clinical Investigation. 2014;124(10):4529-4538.
Andersson E.I., Rajala H.L.M., Eldfors S., Ellonen P., Olson T., Jerez A., Clemente M.J., Kallioniemi O., Porkka K., Heckman C., Loughran T.P., Maciejewski J.P., Mustjoki S. Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation Blood Cancer Journal. 2013;3(12)
Clemente M.J., Przychodzen B., Jerez A., Dienes B.E., Afable M.G., Husseinzadeh H., Rajala H.L.M., Wlodarski M.W., Mustjoki S., Maciejewski J.P. Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes Blood. 2013;122(25):4077-4085.
Gómez-Seguí I., Makishima H., Jerez A., Yoshida K., Przychodzen B., Miyano S., Shiraishi Y., Husseinzadeh H.D., Guinta K., Clemente M., Hosono N., McDevitt M.A., Moliterno A.R., Sekeres M.A., Ogawa S., MacIejewski J.P. Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies Leukemia. 2013;27(9):1943-1946.
Jerez A., Clemente M.J., Makishima H., Rajala H., Goḿez-Seguí I., Olson T., McGraw K., Przychodzen B., Kulasekararaj A., Afable M., Husseinzadeh H.D., Hosono N., LeBlanc F., Lagstrom̈ S., Zhang D., Ellonen P., Tichelli A., Nissen C., Lichtin A.E., Wodnar-Filipowicz A., Mufti G.J., List A.F., Mustjoki S., Loughran T.P., Maciejewski J.P. STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients Blood. 2013;122(14):2453-2459.
Rajala H.L.M., Eldfors S., Kuusanmäki H., Van Adrichem A.J., Olson T., Lagström S., Andersson E.I., Jerez A., Clemente M.J., Yan Y., Zhang D., Awwad A., Ellonen P., Kallioniemi O., Wennerberg K., Porkka K., Maciejewski J.P., Loughran T.P., Heckman C., Mustjoki S. Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia Blood. 2013;121(22):4541-4550.
Jerez A., Clemente M.J., Makishima H., Koskela H., LeBlanc F., Ng K.P., Olson T., Przychodzen B., Afable M., Gomez-Segui I., Guinta K., Durkin L., Hsi E.D., McGraw K., Zhang D., Wlodarski M.W., Porkka K., Sekeres M.A., List A., Mustjoki S., Loughran T.P., Maciejewski J.P. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia Blood. 2012;120(15):3048-3057.
Koskela H.L.M., Eldfors S., Ellonen P., Van Adrichem A.J., Kuusanmäki H., Andersson E.I., Lagström S., Clemente M.J., Olson T., Jalkanen S.E., Majumder M.M., Almusa H., Edgren H., Lepistö M., Mattila P., Guinta K., Koistinen P., Kuittinen T., Penttinen K., Parsons A., Knowles J., Saarela J., Wennerberg K., Kallioniemi O., Porkka K., Loughran T.P., Heckman C.A., Maciejewski J.P., Mustjoki S. Somatic STAT3 mutations in large granular lymphocytic leukemia New England Journal of Medicine. 2012;366(20):1905-1913.
Makishima H., Sugimoto Y., Szpurka H., Clemente M.J., Ng K.P., Muramatsu H., O'Keefe C., Saunthararajah Y., MacIejewski J.P. CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors Leukemia. 2012;26(7):1547-1554.
Nyland S.B., Krissinger D.J., Clemente M.J., Irby R.B., Baab K.T., Jarbadan N.R., Sokol L., Schaefer E., Liao J., Cuthbertson D., Epling-Burnette P., Paquette R., List A.F., Maciejewski J.P., Loughran T.P. Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone marrow failure consortium study Leukemia Research. 2012;36(5):581-587.
Sugimori C., Padron E., Caceres G., Shain K., Sokol L., Zhang L., Tiu R., O'Keefe C.L., Afable M., Clemente M., Lee J.M., MacIejewski J.P., List A.F., Epling-Burnette P.K., Araten D.J. Paroxysmal nocturnal hemoglobinuria and concurrent JAK2 V617F mutation Blood Cancer Journal. 2012;2(3)
Afable M., Shaik M., Sugimoto Y., Elson P., Clemente M., Makishima H., Sekeres M., Lichtin A., Advani A., Kalaycio M., Tiu R., O'Keefe C., Maciejewski J. Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia Haematologica. 2011;96(9):1269-1275.
Clemente M.J., Wlodarski M.W., Makishima H., Viny A.D., Bretschneider I., Shaik M., Bejanyan N., Lichtin A.E., His E.D., Paquette R.L., Loughran T.P., Maciejewski J.P. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia Blood. 2011;118(16):4383-4393.
Jankowska A., Szpurka H., Calabro M., Mohan S., Schade A., Clemente M., Silverstein R., Maciejewski J. Loss of expression of neutrophil proteinase-3: A factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria Haematologica. 2011;96(7):954-962.
O'Keefe C., Sugimori C., Afable M., Clemente M., Shain K., Araten D., List A., Epling-Burnette P., MacIejewski J. Deletions of Xp22.2 including PIG-A locus lead to paroxysmal nocturnal hemoglobinuria Leukemia. 2011;25(2):379-382.
Viny A.D., Clemente M.J., Jasek M., Askar M., Ishwaran H., Nowacki A., Zhang A., Maciejewski J.P. MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia Haematologica. 2010;95(10):1713-1721.
Mohan S., Clemente M., Afable M., Cazzolli H., Bejanyan N., Wlodarski M., Lichtin A., Maciejewski J. Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia Haematologica. 2009;94(10):1407-1414.
Augustine J.J., Poggio E.D., Clemente M., Aeder M.I., Bodziak K.A., Schulak J.A., Heeger P.S., Hricik D.E. Hemodialysis vintage, black ethnicity, and pretransplantation antidonor cellular immunity in kidney transplant recipients Journal of the American Society of Nephrology. 2007;18(5):1602-1606.
Poggio E.D., Augustine J.J., Clemente M., Danzig J.M., Volokh N., Zand M.S., Hricik D.E., Heeger P.S. Pretransplant cellular alloimmunity as assessed by a panel of reactive T cells assay correlates with acute renal graft rejection Transplantation. 2007;83(7):847-852.
Poggio E.D., Clemente M., Hricik D.E., Heeger P.S. Panel of reactive T cells as a measurement of primed cellular alloimmunity in kidney transplant candidates Journal of the American Society of Nephrology. 2006;17(2):564-572.
Augustine J.J., Siu D.S., Clemente M.J., Schulak J.A., Heeger P.S., Hricik D.E. Pre-transplant IFN-γ ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients American Journal of Transplantation. 2005;5(8):1971-1975.
Poggio E.D., Roddy M., Riley J., Clemente M., Hricik D.E., Starling R., Young J.B., Gus B., Yamani M.H., Heeger P.S. Analysis of immune markers in human cardiac allograft recipients and association with coronary artery vasculopathy Journal of Heart and Lung Transplantation. 2005;24(10):1606-1613.
Roddy M., Clemente M., Poggio E.D., Bukowski R., Thakkar S., Waxenecker G., Loibner H., Himmler G., Hricik D.E., Heeger P.S. Heterogeneous alterations in human alloimmunity associated with immunization Transplantation. 2005;80(3):297-302.
Poggio E.D., Clemente M., Riley J., Roddy M., Greenspan N.S., Dejelo C., Najafian N., Sayegh M.H., Hricik D.E., Heeger P.S. Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy Journal of the American Society of Nephrology. 2004;15(7):1952-1960.