Clinical Assistant Professor, Department of Medicine
Biosketch
Zhigang Liu, MD, PhD, is a board certified cardiologist and cardiac electrophysiologist with Ascension Borgess Heart Institute in Kalamazoo, Michigan. He is a graduate of Southeast University School of Medicine in Nanjing, China, and Wayne State University School of Medicine in Detroit, Michigan. He completed his Internal Medicine residency training at MedStar Harbor Medical Center in Baltimore, Maryland. He received his general Cardiology fellowship training from University of Cincinnati in Cincinnati, Ohio. He finished additional fellowship training in Clinical Cardiac Electrophysiology at University of Michigan in Ann Arbor, Michigan. His clinical, teaching, and research interests include medical education, cardiology and cardiac electrophysiology.
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Education and Training
- Fellowship 2020, Cardiac Electrophysiology, University of Michigan Health System
- Fellowship 2018, Cardiovascular Disease, Medical Center, University of Cincinnati
- Residency 2015, Internal Medicine, MedStar Harbor Medical Center
- PhD 2011, Biochemistry and Molecular Biology, School of Medicine, Wayne State University
- MD 2005, Southeast University School of Medicine
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Research
- Internal Medicine
- Cardiology
- Cardiac Electrophysiology
- Biochemistry
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Publications
Jamé S., Liu Z., Kolias T., Liang J., Labounty T., Ghannam M., Latchamsetty R., Jongnarangsin K., Morady F., Bogun F. Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation Journal of Clinical Medicine. 2023;12
Ghannam M., Jame S., Jongnarangsin K., Cheng Y.W., Gunda S., Fadahunsi O., Hughey A., Liu Z., Shantha G., Chokesuwattanaskul R., Yokokawa M., Oral H., Morady F., Chugh A. Catheter ablation of the left and right atrial appendages without isolation in persistent atrial fibrillation Heart Rhythm. 2021;18:694-701.
Baykaner T., Quadros K.K., Thosani A., Yasmeh B., Mitra R., Liu E., Belden W., Liu Z., Costea A., Brodt C.R., Zei P.C. Safety and efficacy of zero fluoroscopy transseptal puncture with different approaches PACE - Pacing and Clinical Electrophysiology. 2020;43(1):12-18.
Liu Z., Yasmeh B., Verdick C., Rajsheker S., Barone A., Costea A. New trends in high risk ventricular tachycardia catheter ablation Journal of Cardiovascular Disease Research. 2019;10(1):1-8.
Karan G., Wang H., Chakrabarti A., Karan S., Liu Z., Xia Z., Gundluru M., Moreton S., Saunthararajah Y., Jackson M.W., Agarwal M.K., Wald D.N. Identification of a small molecule that overcomes HdmX-mediated suppression of p53 Molecular Cancer Therapeutics. 2016;15(4):574-582.
Yedidi R.S., Liu Z., Kovari I.A., Woster P.M., Kovari L.C. P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease Journal of Molecular Graphics and Modelling. 2014;47:18-24.
Yedidi R.S., Proteasa G., Martin P.D., Liu Z., Vickrey J.F., Kovari I.A., Kovari L.C. A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF Journal of Molecular Graphics and Modelling. 2014;53:105-111.
Dewdney T.G., Wang Y., Liu Z., Sharma S.K., Reiter S.J., Brunzelle J.S., Kovari I.A., Woster P.M., Kovari L.C. Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease Bioorganic and Medicinal Chemistry. 2013;21(23):7430-7434.
Liu Z., Wang Y., Yedidi R.S., Dewdney T.G., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C. Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes Biochemical and Biophysical Research Communications. 2013;430(3):1022-1027.
Liu Z., Yedidi R.S., Wang Y., Dewdney T.G., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C. Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance Biochemical and Biophysical Research Communications. 2013;437(2):199-204.
Liu Z., Yedidi R.S., Wang Y., Dewdney T.G., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C. Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex Biochemical and Biophysical Research Communications. 2013;431(2):232-238.
Yedidi R.S., Muhuhi J.M., Liu Z., Bencze K.Z., Koupparis K., O'Connor C.E., Kovari I.A., Spaller M.R., Kovari L.C. Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease Biochemical and Biophysical Research Communications. 2013;438(4):703-708.
Liu Z., Wang Y., Yedidi R.S., Brunzelle J.S., Kovari I.A., Sohi J., Kamholz J., Kovari L.C. Crystal structure of the extracellular domain of human myelin protein zero Proteins: Structure, Function and Bioinformatics. 2012;80(1):307-313.
Wang Y., Dewdney T.G., Liu Z., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C. Higher desolvation energy reduces molecular recognition in multi-drug resistant HIV-1 protease Biology. 2012;1(1):81-93.
Yedidi R.S., Liu Z., Wang Y., Brunzelle J.S., Kovari I.A., Woster P.M., Kovari L.C., Gupta D. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds Biochemical and Biophysical Research Communications. 2012;421(3):413-417.
Liu Z., Wang Y., Brunzelle J., Kovari I.A., Kovari L.C. Nine crystal structures determine the substrate envelope of the MDR HIV-1 protease Protein Journal. 2011;30(3):173-183.
Wang Y., Dewdney T.G., Liu Z., Reiter S.J., Brunzelle J.S., Kovari I.A., Kovari L.C. X-ray crystal structure and dynamics reveal HIV-1 protease drug interactions Studia Universitatis Babes-Bolyai Chemia. 2011(3):221-230.
Wang Y., Liu Z., Brunzelle J.S., Kovari I.A., Dewdney T.G., Reiter S.J., Kovari L.C. The higher barrier of darunavir and tipranavir resistance for HIV-1 protease Biochemical and Biophysical Research Communications. 2011;412(4):737-742.
Yedidi R.S., Proteasa G., Martinez J.L., Vickrey J.F., Martin P.D., Wawrzak Z., Liu Z., Kovari I.A., Kovari L.C. Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: Crystallographic study of MDR769 HIV-1 protease variants Acta Crystallographica Section D: Biological Crystallography. 2011;67(6):524-532.