Assistant Professor, Department of Orthopaedic Surgery
Assistant Professor, Program in Medical Engineering
Biosketch
Adil Akkouch, PhD, received his master's degree in Experimental Medicine and his PhD in Tissue Engineering and Regenerative Medicine at the Laval University of Quebec City, Quebec Canada. He also completed two postdoctoral trainings at the University of Iowa, in the Department of mechanical engineering and in the school of Dentistry before accepting a faculty position at Western Michigan University, School of Medicine. His research interests include hard and soft tissue engineering, 3D bioprinting and microRNA-based gene therapy.
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Education and Training
- Postdoctoral Research Fellowship 2017, MicroRNA Based Gene Therapy, College of Dentistry, University of Iowa
- Postdoctoral Research Fellowship 2015, 3D Bioprinting, College of Engineering, University of Iowa
- PhD 2012, Tissue Engineering, School of Medicine, Université Laval
- MSc 2008, Tissue Engineering, School of Medicine, Université Laval
- BS 2004, Human Physiology, Faculty of Sciences, Université Ibn Tofail
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Research
- gene therapy
- Tissue Engineering
- 3D bioprinting
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Publications
Frase D., Lee C., Nachiappan C., Gupta R., Akkouch A. The Inflammatory Contribution of B-Lymphocytes and Neutrophils in Progression to Osteoporosis Cells. 2023;12
Gupta R., Grove K., Wei A., Lee J., Akkouch A. Ankle and Foot Arthroplasty and Prosthesis: A Review on the Current and Upcoming State of Designs and Manufacturing Micromachines. 2023;14
Chaney S., Vergara R., Qiryaqoz Z., Suggs K., Akkouch A. The Involvement of Neutrophils in the Pathophysiology and Treatment of Osteoarthritis Biomedicines. 2022;10
Jin M., Chung H., Kwon P., Akkouch A. Effects of Different Titanium Surfaces Created by 3D Printing Methods, Particle Sizes, and Acid Etching on Protein Adsorption and Cell Adhesion, Proliferation, and Differentiation Bioengineering. 2022;9
Krongbaramee T., Zhu M., Qian Q., Zhang Z., Eliason S., Shu Y., Qian F., Akkouch A., Su D., Amendt B.A., Yang L., Hong L. Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice Molecular Therapy Nucleic Acids. 2021;23:1204-1216.
Remy M.T., Akkouch A., He L., Eliason S., Sweat M.E., Krongbaramee T., Fei F., Qian F., Amendt B.A., Song X., Hong L. Rat Calvarial Bone Regeneration by 3D-Printed β-Tricalcium Phosphate Incorporating MicroRNA-200c ACS Biomaterials Science and Engineering. 2021;7:4521-4534.
Akkouch A., Eliason S., Sweat M.E., Romero-Bustillos M., Zhu M., Qian F., Amendt B.A., Hong L. Enhancement of MicroRNA-200c on osteogenic differentiation and bone regeneration by targeting Sox2-Mediated Wnt Signaling and Klf4 Human Gene Therapy. 2019;30:1405-1418.
Akkouch A., Zhu M., Romero-Bustillos M., Eliason S., Qian F., Salem A.K., Amendt B.A., Hong L. MicroRNA-200c Attenuates Periodontitis by Modulating Proinflammatory and Osteoclastogenic Mediators Stem Cells and Development. 2019;28:1026-1036.
Remy M.T., Akkouch A., He L., Sweat M., Qian F., Song X., Amendt B.A., Hong L. MicroRNA-200c incorporated 3D-printed tricalcium phosphate enhances bone regeneration Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 2019;40:332.
Denry I., Goudouri O.M., Fredericks D.C., Akkouch A., Acevedo M.R., Holloway J.A. Strontium-releasing fluorapatite glass-ceramic scaffolds: Structural characterization and in vivo performance Acta Biomaterialia. 2018;75:463-471.
Do A.V., Akkouch A., Green B., Ozbolat I., Debabneh A., Geary S., Salem A.K. Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes Annals of Biomedical Engineering. 2017;45:297-305.
Hong L., Sharp T., Khorsand B., Fischer C., Eliason S., Salem A., Akkouch A., Brogden K., Amendt B.A. MicroRNA-200c represses IL-6, IL-8, and CCL-5 expression and enhances osteogenic differentiation PLoS ONE. 2016;11
Akkouch A., Yu Y., Ozbolat I.T. Microfabrication of scaffold-free tissue strands for three-dimensional tissue engineering Biofabrication. 2015;7
Zhang Y., Yu Y., Akkouch A., Dababneh A., Dolati F., Ozbolat I.T. In vitro study of directly bioprinted perfusable vasculature conduits Biomaterials Science. 2015;3:134-143.
Akkouch A., Zhang Z., Rouabhia M. Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (l-lactide-co-É-caprolactone) scaffold Journal of Biomaterials Applications. 2014;28:922-936.
Rouabhia M., Akkouch A., Zhang Z. Potential use of bone tissue engineering to treat human bone defects Bone Grafts: Procedures, Complications and Alternatives. 2013:13-27.
Tazi N., Chmielewski W., Semlali A., Lamkhioued B., Akkouch A., Clavette M., Ghannoum M., Rouabhia M. Evaluation of C. albicans adhesion and growth on restorative dental materials enriched or not with fluoride Journal of Microbial and Biochemical Technology. 2012;4:15-21.
Akkouch A., Zhang Z., Rouabhia M. A novel collagen/hydroxyapatite/poly(lactide-co-Îμ-caprolactone) biodegradable and bioactive 3D porous scaffold for bone regeneration Journal of Biomedical Materials Research - Part A. 2011;96 A:693-704.
Akkouch A., Shi G., Zhang Z., Rouabhia M. Bioactivating electrically conducting polypyrrole with fibronectin and bovine serum albumin Journal of Biomedical Materials Research - Part A. 2010;92:221-231.
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Presentations
- Integration of poly(glycerol sebacate) and polycaprolactone scaffolds for enhanced tendon regeneration. Lee C, Kenter M, Kenter K, Akkouch A, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- Effects of different PEEK fabrication methods on surface wettability and cellular response. Brown LC, Kenter M, Brandon A, Akkouch A, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- The effects of hyperglycemia on osteoblasts proliferation and differentiation. Grove K, Kenter M, Akkouch A, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- Combinatory effect of niobium and strontium on osteogenesis. Ellythy S, Chaney S, Kenter M, Akkouch A, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- Development of smart antibacterial mesh for abdominal wall repair. Akkouch A, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- 3D printed electrically conductive scaffolds to restore bone environment. Ranat K, Kenter M, Williams L, Kenter K, Akkouch A, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- Tendon Repair Using Biodegradable and Bioactive 3D Poly (Glycerol Sebacate) Scaffolds. Lee C, Kenter M, Kenter K, Akkouch A, 41st Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Development of Antibacterial Mesh for Abdominal Wall Repair. Zhang M, Kenter M, Nachiappan C, Kenter K, Sawyer R, Akkouch A, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- miR-200a Attenuates Osteoblasts Activity in Response to Low-Density Lipoproteins. Phan H, Frase D, Ruell L, Akkouch A, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Potential of Acetylcholine to Improve Rotator Cuff Patch Repair. Trivedi R, Kenter M, Kenter K, Akkouch A, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Synthesis of a GO/DMSO-doped PEDOT Electroactive Nanocomposite for Electrical Stimulation Therapy. Kenter M, Kenter K, Akkouch A, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- The Effect of PEDOT Concentrations on MEW PEDOT Scaffold Mechanical Properties. Ranat K, Kenter M, Kenter K, Akkouch A, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Blood Clots as Biologically Active Scaffolds for Chondrogenesis and Osteogenesis. Richter D, Keckler K, Hung V, Morrey L, Abd G, Bailey K, Kenter M, Akkouch A, Li Y, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Chondroprotective Effect of Strontium Through the Inhibition of ADAMTS-4 and ADAMTS-5 in Human Chondrocytes. Chaney S, Kenter M, Qiryadoz Z, Akkouch A, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Ankle and Foot Arthroplasty and Prosthesis: A Review on the Current and Upcoming State of Designs and Manufacturing. Gupta R, Grove K, Lee J, Wei A, Akkouch A, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Biomimetic Scaffolds for Bone Regeneration Using 3D Melt Electrowriting. Randhawa M, Ranat K, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Strontium Decreases Mitochondrial Reactive Oxygen Species Production in Chondrocyte Spheroids. Chaney S, Qiryaqoz Z, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Biocompatibility Analysis of 3D Bioprinted Construct for Enhanced Bone Regeneration. Qiryaqoz Z, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Fabrication of 3D Electroconductive Scaffold for Bone Regeneration. Ranat K, Kenter M, Kenter K, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Impact of Acetylcholine on Osteoblast Differentiation and Activity in vitro. Trivedi R, Kenter K, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Effect of Strontium and Niobium on Bone Proliferation and Differentiation. Ellythy S, Chaney S, Kenter K, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- The Effect of Low-Density Lipoproteins on miRNA Expression on Osteoblasts. Phan H, Ruell L, Springstead J, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- The Effect of Low-Density Lipoprotein Particles on Osteoblast Differentiation. Ruell L, Phan H, Springstead J, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- A Role for Cut homeobox 1 in Scoliosis Pathogenesis and Spine Deformity. Beck E, Vanden Heuvel G, Akkouch A, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Quantitative Analysis of Bone Formation by Micro-Computed Tomography. Manawar S, Akkouch A, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Synthesis of a GO/PEDOT-DMSO Electroactive Nanocomposite for Tissue Engineering Application. Kenter M, Akkouch A, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Design and Fabrication of a Knee-on-a-Chip Microdevice Using 3D Printing. Thottathil L, Akkouch A, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Synthesis of a Novel GO/DMSO-DOPED PEDOT Electroactive Nanocomposite for Bioelectrical Stimulation. Kenter M, Akkouch A, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Fabrication of PLLA/PDS-PEDOT Nanoscaffolds Using 3D Melt Electrowriting For Bone Regeneration. Kenter M, Akkouch A, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Controlled-Assembly of Chondrocyte Spheroids Using 3D Printed Molds. Chaney S, Qiryaqoz Z, Akkouch A, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021