Xiaoke Liu, MD, PhD, MSc
Clinical Assistant Professor, Department of Medicine
Biosketch
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Board Certification
- American Board of Internal Medicine (Internal Medicine)
- Board Certified in Cardiology
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Education and Training
- Fellowship 2008, Cardiology, Mayo Clinic - Rochester, MN,
- Internship 2003, Internal Medicine Internship and Residency, Mayo Clinic - Rochester, MN,
- PhD 1999, Cardiac Electrophysiology and Pharmacology, Georgetown University
- MSc 1994, Clinical Pharmacology, Hunan Medical University - Changsha, China,
- MD 1991, Hunan Medical University - Changsha, China,
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Research
- Cardiovascular Diseases
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Publications
Holmuhamedov E.L., Chakraborty P., Oberlin A., Liu X., Yousufuddin M., Shen W.K., Terzic A., Jahangir A. Aging-associated susceptibility to stress-induced ventricular arrhythmogenesis is attenuated by tetrodotoxin Biochemical and Biophysical Research Communications. 2022;623:44-50.
Liu X., Wu S.I. Author's Reply—A double-blind case study? HeartRhythm Case Reports. 2021;7:259-260.
Liu X., Wu S.I. Successful fluoroless deviation of the esophagus during atrial fibrillation ablation HeartRhythm Case Reports. 2021;7:213-215.
Liu X., Liu X. Response to “letter to editor” PACE - Pacing and Clinical Electrophysiology. 2019;42:294.
Liu X., Liu X., Palmer J., Palmer J. Outcomes of 200 consecutive, fluoroless atrial fibrillation ablations using a new technique PACE - Pacing and Clinical Electrophysiology. 2018;41:1404-1411.
Liu X., Pratt J., Palmer J. Successful fluoroless ablation of an incessant atypical atrial flutter attributed to AtriClip usage during mini-MAZE surgery for persistent atrial fibrillation HeartRhythm Case Reports. 2017;3:352-356.
Ahmad K., Asirvatham S., Kamath S., Peck S., Liu X. Successful interventional management of catastrophic coronary arterial air embolism during atrial fibrillation ablation HeartRhythm Case Reports. 2016;2:153-156.
Liu X., Asirvatham S., Kabell G.G. Orthostatic increase in defibrillation threshold leading to defibrillation failure and prolonged cardiac arrest in a sitting position: Lessons from a patient's near-fatal experience HeartRhythm Case Reports. 2016;2:313-317.
Patel S.M., McLeod C.J., Friedman P.A., Liu X.K., Asirvatham S.J. Successful ablation of a left-sided accessory pathway in a patient with coronary sinus atresia and arteriovenous fistula: Clinical and developmental insights Indian Pacing and Electrophysiology Journal. 2011;11:43-49.
Liu X.K., Barrett R., Packer D.L., Asirvatham S.J. Successful management of recurrent ventricular tachycardia by electrical isolation of anterolateral papillary muscle Heart Rhythm. 2008;5:479-482.
Liu X.K., Gersh B.J., Cha Y.M. Cardiomyopathy induced by pulmonary vein tachycardia cured by catheter ablation Nature Clinical Practice Cardiovascular Medicine. 2008;5:406-410.
Yamada S., Nelson T.J., Crespo-Diaz R.J., Perez-Terzic C., Liu X.K., Miki T., Seino S., Behfar A., Terzic A. Embryonic stem cell therapy of heart failure in genetic cardiomyopathy Stem Cells. 2008;26:2644-2653.
Olson T.M., Alekseev A.E., Moreau C., Liu X.K., Zingman L.V., Asirvatham S.J., Jahangir A., Terzic A., Miki T. K<inf>ATP</inf> channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation Nature Clinical Practice Cardiovascular Medicine. 2007;4:110-116.
Kane G.C., Behfar A., Dyer R.B., O'Cochlain D.F., Liu X.K., Hodgson D.M., Reyes S., Miki T., Seino S., Terzic A. KCNJ11 gene knockout of the Kir6.2 K<inf>ATP</inf> channel causes maladaptive remodeling and heart failure in hypertension Human Molecular Genetics. 2006;15:2285-2297.
Kane G.C., Lam C.F., O'Cochlain F., Hodgson D.M., Reyes S., Liu X.K., Miki T., Seino S., Katusic Z.S., Terzic A. Gene knockout of the KCNJ8-encoded Kir6.1 K<inf>ATP</inf> channel imparts fatal susceptibility to endotoxemia FASEB Journal. 2006;20:2271-2280.
Olson T.M., Alekseev A.E., Liu X.K., Park S., Zingman L.V., Bienengraeber M., Sattiraju S., Ballew J.D., Jahangir A., Terzic A. Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation Human Molecular Genetics. 2006;15:2185-2191.
Yamada S., Kane G.C., Behfar A., Liu X.K., Dyer R.B., Faustino R.S., Miki T., Seino S., Terzic A. Protection conferred by myocardial ATP-sensitive K<sup>+</sup> channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant Journal of Physiology. 2006;577:1053-1065.
Kane G.C., Liu X.K., Yamada S., Olson T.M., Terzic A. Cardiac K<inf>ATP</inf> channels in health and disease Journal of Molecular and Cellular Cardiology. 2005;38:937-943.
Liu X.K., Jahangir A., Terzic A., Gersh B.J., Hammill S.C., Shen W.K. Age- and sex-related atrial electrophysiologic and structural changes American Journal of Cardiology. 2004;94:373-375.
Liu X.K., Yamada S., Kane G.C., Alekseev A.E., Hodgson D.M., O'Cochlain F., Jahangir A., Miki T., Seino S., Terzic A. Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K<sup>+</sup> channel, predisposes to catecholamine-induced ventricular dysrhythmia Diabetes. 2004;53
O'Cochlain D.F., Perez-Terzic C., Reyes S., Kane G.C., Behfar A., Hodgson D.M., Strommen J.A., Liu X.K., van den Broek W., Wansink D.G., Wieringa B., Terzic A. Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myophaty and hypotension traits of myotonic dystrophy Human Molecular Genetics. 2004;13:2505-2518.
Liu X.K., Katchman A., Whitfield B.H., Wan G., Janowski E.M., Woosley R.L., Ebert S.N. In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits Cardiovascular Research. 2003;57:28-36.
Rodriguez I., Kilborn M.J., Liu X.K., Pezzullo J.C., Woosley R.L. Drug-induced QT prolongation in women during the menstrual cycle JAMA. 2001;285:1322-1326.
Drici M.D., Ebert S.N., Wang W.X., Rodriguez I., Liu X.K., Whitfield B.H., Woosley R.L. Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart Journal of Cardiovascular Pharmacology. 1999;34:82-88.
Liu X.K., Wang W., Ebert S.N., Franz M.R., Katchman A., Woosley R.L. Female gender is a risk factor for torsades de pointes in an in vitro animal model Journal of Cardiovascular Pharmacology. 1999;34:287-294.
Drici M.D., Wang W.X., Liu X.K., Woosley R.L., Flockhart D.A. Prolongation of QT interval in isolated feline hearts by antipsychotic drugs Journal of Clinical Psychopharmacology. 1998;18:477-481.
Ebert S.N., Liu X.K.E., Woosley R.L. Female gender as a risk factor for drug-induced cardiac arrhythmias: Evaluation of clinical and experimental evidence Journal of Women's Health. 1998;7:547-557.
Liu X.K., Abernethy D.R., Andrawis N.S. Nitric oxide inhibits Oct-1 DNA binding activity in cultured vascular smooth muscle cells Life Sciences. 1998;62:739-749.
Liu X.K., Katchman A., Drici M.D., Ebert S.N., Ducic I., Morad M., Woosley R.L. Gender difference in the cycle length-dependent QT and potassium currents in rabbits Journal of Pharmacology and Experimental Therapeutics. 1998;285:672-679.
Liu X.K.E., Katchman A., Ebert S.N., Woosley R.L. The antiestrogen tamoxifen blocks the delayed rectifier potassium current, IKP in rabbit ventricular myocytes Journal of Pharmacology and Experimental Therapeutics. 1998;287:877-883.
Wang W.X., Ebert S.N., Liu X.K., Chen Y.W., Drici M.D., Woosley R.L. 'Conventional' antihistamines slow cardiac repolarization in isolated perfused (Langendorff) feline hearts Journal of Cardiovascular Pharmacology. 1998;32:123-128.
Liu X.K., Wang W.X., Woosley R.L. Gender affects the rate-dependent prolongation of cardiac repolarization by d-sotalol Clinical Pharmacology and Therapeutics. 1997;61:229.