Assistant Dean for Admissions, Office of the Dean
Associate Professor, Department of Biomedical Sciences
Contact Information
Email:Biosketch
Timothy Bauler, PhD, is an associate professor in the Department of Biomedical Sciences at Western Michigan University Homer Stryker M.D. School of Medicine. He is a graduate of University of Illinois at Urbana-Champaign in Champaign, Illinois. He earned his doctoral degree in microbiology and immunology from University of Michigan in Ann Arbor, Michigan. His graduate research focused on the generation of conditional knockout mice to identify novel negative regulators of proximal T cell receptor signal transduction.
Dr. Bauler completed a postdoctoral fellowship at Rocky Mountain Laboratory, NAIAD, NIH in Hamilton, Montana. He used primary human cells and mouse models and BSL-3 containment to identify virulence mechanisms used by the potential bioterrorism agent Francisella tularensis to evade and suppress the innate immune response. His research also examined the mechanism used by Salmonella Typhimurium to cross the blood-brain barrier.
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Education and Training
- Postdoctoral Fellowship 2015, Host-Pathogen Interactions, Rocky Mountain Laboratories, NIAID, National Institute of Health
- PhD 2009, Microbiology and Immunology, University of Michigan
- BS 2003, Cell and Structural Biology, University of Illinois at Urbana-Champaign
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Research
- Medical Microbiology
- Immunology
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Publications
Greenblatt R.J., Bauler T.J., Higgins B.P., Chamberlain N.R., Kerry J.A. Proceedings of the 18th Microbiology and Immunology Educational Strategies Workshop, July 18–22, 2022 Medical Science Educator. 2024;34:277-278.
Bauler T.J., Sheakley M.L., Turula H., Miller L., Busha M.E. A Virtual Patient Encounter to Promote Integration in a Preclinical Case-Based Learning Session Medical Science Educator. 2023;33:331-332.
Melgar T.A., Bauler T.J., Lutwick L.I. Q fever in man: A one health paradigm disease The Encyclopedia of Bacteriology Research Developments. 2021;11:1689-1712.
Bauler T.J., Sheakley M.L., Ho A. Use of the Team-Based Learning Readiness Assessment Test as a Low-Stakes Weekly Summative Assessment to Promote Spaced and Retrieval-Based Learning Medical Science Educator. 2020;30:605-608.
Bauler T.J., Cole S., Gibb T., Van Enk R., Lutwick L., Dickinson B.L. HIV/AIDS: A case-based learning module for first-year medical students Journal of Microbiology and Biology Education. 2019;19
Sheakley M.L., Bauler T.J., Vandre D.D., Woodwyk A., Dickinson B.L. Effectiveness of instructor-guided independent learning in comparison to traditional didactic lecture in the preclinical medical curriculum: A retrospective cohort study Medical Teacher. 2019;41(7):795-801.
Starr T., Bauler T., Malik-Kale P., Steele-Mortimer O. The phorbol 12-myristate-13-acetate differentiation protocol is critical to the interaction of THP-1 macrophages with Salmonella Typhimurium PLoS ONE. 2018;13(3)
Bauler T.J., Starr T., Nagy T.A., Sridhar S., Scott D., Winkler C.W., Steele-Mortimer O., Detweiler C.S., Peterson K.E. Salmonella Meningitis Associated with Monocyte Infiltration in Mice American Journal of Pathology. 2017;187(1):187-199.
Dickinson B.L., VanDerKolk K., Bauler T., Cole S. Integration of Biomedical Sciences in the Family Medicine Clerkship Using Case-Based Learning Medical Science Educator. 2017;27:815-820.
Melgar T.A., Bauler T.J., Lutwick L.I. Q fever in man: A one health paradigm disease The Principles and Practice of Q Fever: The One Health Paradigm. 2017:1-24.
Bauler T.J., Shattuck B., Van Enk R., Lutwick L., Dickinson B.L. Design and Implementation of an Integrated Course to Teach Immunology and Infectious Disease to First Year Medical Students Medical Science Educator. 2016;26:701-707.
Bauler T., Chase J., Wehrly T., Bosio C. Virulent Francisella tularensis destabilize host mRNA to rapidly suppress inflammation Journal of Innate Immunity. 2014;6(6):793-805.
Crane D., Bauler T., Wehrly T., Bosio C. Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome Frontiers in Microbiology. 2014;5(AUG)
Lubeck B.A., Lapinski P.E., Bauler T.J., Oliver J.A., Hughes E.D., Saunders T.L., King P.D. Blood vascular abnormalities in Rasa1<sup>R780Q</sup> knockin mice: Implications for the pathogenesis of capillary malformation-arteriovenous malformation American Journal of Pathology. 2014;184(12):3163-3169.
He Z., Zhu H.H., Bauler T.J., Wang J., Ciaraldi T., Alderson N., Li S., Raquil M.A., Ji K., Wang S., Shao J., Henry R., King P.D., Feng G.S. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase Proceedings of the National Academy of Sciences of the United States of America. 2013;110(1)
Bauler T., Chase J., Bosio C. IFN-β mediates suppression of IL-12p40 in human dendritic cells following infection with virulent Francisella tularensis Journal of Immunology. 2011;187(4):1845-1855.
Bauler T.J., Kamiya N., Lapinski P.E., Langewisch E., Mishina Y., Wilkinson J.E., Feng G.S., King P.D. Development of severe skeletal defects in induced SHP-2-deficient adult mice: A model of skeletal malformation in humans with SHP-2 mutations DMM Disease Models and Mechanisms. 2011;4(2):228-239.
Bauler T.J., Hendriks W.J.A.J., King P.D. The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction PLoS ONE. 2008;3(12)
Bauler T., Hughes E., Arimura Y., Mustelin T., Saunders T., King P. Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase Journal of Immunology. 2007;178(6):3680-3687.
Lapinski P.E., Bauler T.J., Brown E.J., Hughes E.D., Saunders T.L., King P.D. Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein Genesis. 2007;45(12):762-767.