Community Professor, Department of Biomedical Sciences
Contact Information
Email:Biosketch
Leonard Ginsbert, PhD, is a community professor with the Department of Biomedical Sciences at Western Michigan University Homer Stryker M.D. School of Medicine in Kalamazoo, Michigan. He is a graduate of Albright College in Reading, Pennsylvania. He earned both a master's degree and a doctorate in developmental biology at Temple University in Philadelphia, Pennsylvania.
Dr. Ginsberg is professor emeritus with Western Michigan University Department of Biomedical Sciences, which is where he spent the majority of his career. He served as Associate Dean for the College of Arts and Sciences as well as Associate Vice President for Research for WMU.
Dr. Ginsberg's research interests include molecular biology and in vitro toxicology, the teaching of science, and teaching with technology.
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Education and Training
- PhD 1974, Developmental Biology, Temple University
- MS 1971, Developmental Biology, Temple University
- BS 1969, Biology, Albright College
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Publications
Fisher K.A., Lee S.H., Walker J., Dileto-Fang C., Ginsberg L., Stapleton S.R. Regulation of proximal tubule sodium/hydrogen antiporter with chronic volume contraction American Journal of Physiology - Renal Physiology. 2001;280
Fisher K., Lee S., Walker J., Dileto-Fang C., Ginsberg L., Stapleton S. Chronic regulation of the renal Na<sup>+</sup>/H<sup>+</sup> antiporter isoform NHE-3 with depressed effective arterial volume FASEB Journal. 1998;12
Cramer C., Cooke S., Ginsberg L., Kletzien R., Stapleton S., Ulrich R. Upregulation of glucose‐6‐phosphate dehydrogenase in response to hepatocellular oxidative stress: Studies with diquat Journal of Biochemical Toxicology. 1995;10:293-298.
Holmen S., Vanbrocklin M., Eversole R., Stapleton S., Ginsberg L. Efficient lipid-mediated transfection of DNA into primary rat hepatocytes In Vitro Cellular & Developmental Biology - Animal: Journal of the Society for In Vitro Biology. 1995;31:347-351.
Rank K., Harris P.K., Ginsberg L.C., Stapleton S.R. Isolation and sequence of a rat glucose-6-phosphate dehydrogenase promoter BBA - Gene Structure and Expression. 1994;1217:81-89.
Stapleton S.R., Stevens G.J., Teel J.F., Rank K., Berg E.A., Wu J.Y., Ginsberg L.C., Kletzien R.F. Effects of acetaldehyde on glucose-6-phosphate dehydrogenase activity and mRNA levels in primary rat hepatocytes in culture Biochimie. 1993;75:971-976.
Rank K., McManus T.P., Ginsberg L.C., Ficsor G. Preparation of mouse-sperm DNA for PCR Mutation Research Letters. 1991;264:67-69.
Ulrich R.G., Kilgore K., Sun E.L., Cramer C.T., Ginsberg L.C. An in vitro fluorescence assay for the detection of drug-induced cytoplasmic lamellar bodies Toxicology Mechanisms and Methods. 1991;1:89-105.
Cox J., Dring L., Ginsberg L., Larson P., Constable D., Ulrich R. Distribution and disposition of trospectomycin sulfate in the in vivo rat, perfused rat liver, and cultured rat hepatocytes Drug Metabolism and Disposition. 1990;18:726-731.
Ficsor G., Ginsberg L.C., Klepetka J.F., McManus T.P., Janca F.C., Safron A.D., Rank K. Detection of gene mutations in mouse sperm with polymerase chain reaction (PCR). Progress in clinical and biological research. 1990;340 C:213-222.
Ulrich R., Aspar D., Cramer C., Kletzien R., Ginsberg L. Isolation and culture of hepatocytes from the cynomolgus monkey (Macaca fascicularis) In Vitro Cellular &Developmental Biology. 1990;26:815-823.
Cox J.W., Ulrich R.G., Wynalda M.A., Mckenna R., Larsen E.R., Ginsberg L.C., Epps D.E. Reversible, hepatic, lysosomal phospholipidosis in rat induced by subchronic daily administration of trospectomycin sulfate Biochemical Pharmacology. 1989;38:3535-3541.
Speziale S., Ginsberg L., Paslay J. Effects of lectins and tunicamycin on IL-1 binding to YT cells Lymphokine Research. 1989;8:1-8.
Panda B.B., Ficsor G., Ginsberg L.C. Sperm enzyme activity analysis in individual sperm for detection of heritable mutations in mammals Experientia. 1988;44:253-254.
Holm M., Berger A.E., Swanson K., Ficsor G., Ginsberg L.C. Ethylnitrosourea treatment increases lectin binding to mouse germ cells Toxicology. 1987;46:281-294.
Holm M., Berger A.E., Swanson K., Ginsberg L.C. Effect of trypsinization on lectin binding to germ cells from ICR and T/t6 mice. Biology of reproduction. 1987;37:282-287.
Waibel R., Granet R., Ficsor G., Ginsberg L. Caproyl esterase from rat testis: Purification and action on cumulus cells Gamete Research. 1985;12:75-84.
Ficsor G., Oldford G.M., Loughlin K.R., Panda B.B., Dubien J.L., Ginsberg L.C. Comparison of methods for detecting mitomycin C‐ and ethyl nitrosourea‐induced germ cell damage in mice: Sperm enzyme activities, sperm motility, testis weight Environmental Mutagenesis. 1984;6:287-298.
Waibel R., Ginsberg L.C., Ficsor G. Cytochemical detection of hyaluronidase activity in single human and mouse sperm by an improved substrate-film technique Journal of Histochemistry and Cytochemistry. 1984;32:63-66.
Waibel R., Oldford G.M., Ficsor G., Ginsberg L.C. Histochemical evaluation of sodium aurothiomalate inhibition of mouse sperm enzymes Journal of Reproduction and Fertility. 1984;70:151-155.
Ficsor G., Ginsberg L.C., Oldford G.M., Snoke R.E., Becker R.W. Gelatin-substrate film technique for detection of acrosin in single mammalian sperm Fertility and Sterility. 1983;39:548-552.
Bauer B.J., Blashfield K., Norris R., Buthala D.A., Ginsberg L.C. Immunoglobulin as the major low density lipoprotein binding protein in plasma Atherosclerosis. 1982;44:153-160.
Copeland E.J., Ginsberg L.C. Major plasma glycoproteins of diabetic and nondiabetic chinese hamsters Journal of Heredity. 1982;73:311-313.
Copeland J., Blashfield K., Bauer B., Gerritsen G., Ginsberg L. Plasma glycoproteins of diabetic and normal Chinese hamsters Experientia. 1982;38:301-302.
Ficsor G., Salama N.M., Block K.K., McIntire C.L., Ginsberg L.C. Germ cell‐specific decrease of acrosomal proteolytic activity, sperm motility, and number in mitomycin C‐treated mice Teratogenesis, Carcinogenesis, and Mutagenesis. 1982;2:13-18.
Ginsberg L., Wyse B., Chang A. Analysis of glycosaminoglycan from diabetic and normal Chinese hamster cells Diabetes. 1981;30:393-395.
Ginsberg L.C., Johnson S.C., Salama N., Ficsor G. Acrosomal proteolytic assay for detection of mutagens in mammals Mutation Research Letters. 1981;91:413-418.
Ficsor G., Ginsberg L.C. The effect of hydroxyurea and mitomycin C on sperm motility in mice Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1980;70:383-387.
Di Ferrante N., Ginsberg L.C., Donnelly P.V., Di Ferrante D.T., Caskey C.T. Deficiencies of glucosamine-6-sulfate or galactosamine-6-sulfate sulfatases are responsible for different mucopolysaccharidoses Science. 1978;199:79-81.
Ginsberg L.C., Donnelly P.V., Di Ferrante D.T., Ferrante N.D., Caskey C.T. N-acetylglucosamine-6-sulfate sulfatase in man: Deficiency of the enzyme in a new mucopolysaccharidosis Pediatric Research. 1978;12:805-809.
Ginsberg L.C., T. Di Ferrante D., Di Ferrante N. A Substrate for Direct Measurement of L-iduronic Acid 2-sulfate sulfatase Carbohydrate Research. 1978;64:225-235.
Ginsberg L.C., Di Ferrante N. Sensitive methods for the determination of ester sulfate in biological systems Biochemical medicine. 1977;17:80-86.
Ginsberg L., Tavella D., Di Ferrante N. Measurement of L idurono 2 sulfate sulfatase EXCERPTA MED.,AMSTERDAM,I.C.S.. 1976;No. 397
Ginsberg L., Hillman N. ATP metabolism in t(n)/t(n) mouse embryos Journal of Embryology and Experimental Morphology. 1975;33:715-723.
Ginsberg L., Hillman N. Shifts in ATP synthesis during preimplantation stages of mouse embryos Journal of Reproduction and Fertility. 1975;43:83-90.
Ginsberg L., Hillman N. Meiotic drive in t(n) bearing mouse spermatozoa: A relationship between aerobic respiration and transmission frequency Journal of Reproduction and Fertility. 1974;38:157-163.
Ginsberg L., Hillman N. ATP metabolism in cleavage staged mouse embryos Journal of Embryology and Experimental Morphology. 1973;30:267-282.