Research Associate Professor, Department of Biomedical Sciences
Contact Information
Email:Biosketch
James McKim, PhD, is founder and president of IONTOX, a biotechnology company founded in 2014 dedicated to providing expertise to the area of in vitro toxicology, with a mission to build improved methods for predicting human adverse effects from chemical exposure. IONTOX offers advanced in vitro solutions that promise to increase the reliability of in vitro toxicology. This in-turn will reduce animal usage, improve the success of new drug candidates, and provide an advanced method of understanding systemic toxicity.
Dr. McKim is a graduate of Florida Technical College in Orlando, Florida. He earned his doctorate in biochemical and molecular toxicology from Oregon State University in Corvallis, Oregon, and also completed a postdoctoral fellowship in cellular and molecular toxicology with University of Kansas Medical Center in Kansas City, Kansas. Prior to founding IONTOX, he was founder, president, and CEO for CeeTox, and a senior research advisor with Pharmacia, serving as group leader for predictive toxicology.
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Education and Training
- Postdoctoral Fellowship 1992, Cellular and Molecular Toxicology, Medical Center, University of Kansas
- PhD 1989, Biochemical and Molecular Toxicology, Oregon State University
- AS 1982, Ocean Engineering, Florida Technical College
- BS 1982, Environmental Science, Florida Technical College
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Research
- Toxicology
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Publications
McKim J.M., Nichols J.W. Use of physiologically based toxicokinetic models in a mechanistic approach to aquatic toxicology Aquatic Toxicology: Molecular, Biochemical, and Cellular Perspectives. 2018:469-520.
McKim J.M., Lien G.J. Toxic responses of the skin Target Organ Toxicity in Marine and Freshwater Teleosts: Organs. 2017:151-223.
Poth A., Wolf M., Carraway J., McKim J., Coleman K., Hutchinson R., Brown R., Krug H., Bahinski A., Hartung T. From in vivo to in vitro: The medical device testing paradigm shift Altex. 2017;34(4):479-500.
{} Probabilistic hazard assessment for skin sensitiza tion potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships Journal of Applied Toxicology. 2015;35(11):1361-1371.
Stephens M., Taalman R., Knudsen T., McKim J., Harris G., Pamies D., Hartung T. Consensus report on the future of animal-free systemic toxicity testing Altex. 2014;31(3):341-356.
Magee T.V., Brown M.F., Starr J.T., Ackley D.C., Abramite J.A., Aubrecht J., Butler A., Crandon J.L., Dib-Hajj F., Flanagan M.E., Granskog K., Hardink J.R., Huband M.D., Irvine R., Kuhn M., Leach K.L., Li B., Lin J., Luke D.R., Macvane S.H., Miller A.A., McCurdy S., McKim J.M., Nicolau D.P., Nguyen T.T., Noe M.C., O'Donnell J.P., Seibel S.B., Shen Y., Stepan A.F., Tomaras A.P., Wilga P.C., Zhang L., Xu J., Chen J.M. Discovery of dap-3 polymyxin analogues for the treatment of multidrug-resistant gram-negative nosocomial infections Journal of Medicinal Chemistry. 2013;56:5079-5093.
{} A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX. 2012;29(1):3-91.
{} T4 report. An expert consortium review of the EC-commissioned report "Alternative (non-animal) methods for cosmetics testing: Current status and future prospects - 2010" Altex. 2011;28(3):183-209.
Kleinow K.M., Nichols J.W., Hayton W.L., McKim J.M., Barron M.G. Toxicokinetics in fishes The Toxicology of Fishes. 2008:55-152.
Erickson R., McKim J., Lien G., Hoffman A., Batterman S. Uptake and elimination of ionizable organic chemicals at fish gills: I. Model formulation, parameterization, and behavior Environmental Toxicology and Chemistry. 2006;25(6):1512-1521.
Erickson R., McKim J., Lien G., Hoffman A., Batterman S. Uptake and elimination of ionizable organic chemicals at fish gills: II. Observed and predicted effects of pH, alkalinity, and chemical properties Environmental Toxicology and Chemistry. 2006;25(6):1522-1532.
Kolanczyk R., Fitzsimmons P., McKim J., Erickson R., Schmieder P. Effects of anesthesia (tricaine methanesulfonate, MS222) on liver biotransformation in rainbow trout (Oncorhynchus mykiss) Aquatic Toxicology. 2003;64(2):177-184.
Lien G., McKim J., Hoffman A., Jenson C. A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush) Aquatic Toxicology. 2001;51(3):335-350.
Hoffman A., Jenson C., Lien G., McKim J. Individual tissue weightto total body weight relationships and total, polar, and nonpolar lipids in tissues of hatchery lake trout Transactions of the American Fisheries Society. 1999;128(1):178-181.
McKim J., Kolanczyk R., Lien G., Hoffman A. Dynamics of renal excretion of phenol and major metabolites in the rainbow trout (Oncorhynchus mykiss) Aquatic Toxicology. 1999;45(4):265-277.
McKim J.M., Lien G.J., Hoffman A.D., Jenson C.T. Respiratory-cardiovascular physiology and xenobiotic gill flux in the lake trout (Salvelinus namaycush) Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 1999;123(1):69-81.
McKim J., Nichols J., Lien G., Hoffman A., Gallinat C., Stokes G. Dermal absorption of three waterborne chloroethanes in rainbow trout (Oncorhynchus mykiss) and channel catfish (Ictalurus punctatus) Fundamental and Applied Toxicology. 1996;31(2):218-228.
Nichols J., McKim J., Lien G., Hoffman A., Bertelsen S., Elonen C. A physiologically based toxicokinetic model for dermal absorption of organic chemicals by fish Fundamental and Applied Toxicology. 1996;31(2):229-242.
Lien G., Nichols J., McKim J., Gallinat C. Modeling the accumulation of three waterborne chlorinated ethanes in fathead minnows (Pimephales promelas): A physiologically based approach Environmental Toxicology and Chemistry. 1994;13(7):1195-1205.
McKim J.M., Nichols J.W., Lien G.J., Bertelsen S.L. Respiratory‐cardiovascular physiology and chloroethane gill flux in the channel catfish, Ictalurus punctatus Journal of Fish Biology. 1994;44(3):527-547.
Nichols J., Rheingans P., Lothenbach D., McGeachie R., Skow L., McKim J. Three-dimensional visualization of physiologically based kinetic model outputs Environmental Health Perspectives. 1994;102(11):952-956.
Lien G.J., McKim J.M. Predicting branchial and cutaneous uptake of 2,2′,5,5′-tetrachlorobiphenyl in fathead minnows (Pimephales promelas) and Japanese medaka (Oryzias latipes): Rate limiting factors Aquatic Toxicology. 1993;27(1-2):15-31.
Mckim J.M., Naumann S., Hammermeister D.E., Hoffman A.D., Klaassen C.D. In Vivo microdialysis sampling of phenol and phenyl glucuronidein the blood of unanesthetized rainbow trout: Implications for toxicokinetic studies Toxicological Sciences. 1993;20(2):190-198.
Nichols J., McKim J., Lien G., Hoffman A., Bertelsen S., Gallinat C. Physiologically-based toxicokinetic modeling of three waterborne chloroethanes in channel catfish, Ictalurus punctatus Aquatic Toxicology. 1993;27(1-2):83-111.
Nichols J., McKim J., Lien G., Hoffman A., Bertelsen S. Physiologically based toxicokinetic modeling of three waterborne chloroethanes in rainbow trout (Oncorhynchus mykiss) Toxicology and Applied Pharmacology. 1991;110(3):374-389.
Niemi G.J., Bradbury S.P., McKim J.M. Use of fish physiology literature for predicting fish acute toxicity syndromes ASTM Special Technical Publication. 1991(1124):245-260.
Erickson R., McKim J. A model for exchange of organic chemicals at fish gills: flow and diffusion limitations Aquatic Toxicology. 1990;18(4):175-197.
Erickson R., McKim J. A simple flow‐limited model for exchange of organic chemicals at fish gills Environmental Toxicology and Chemistry. 1990;9(2):159-165.
Nichols J.W., McKim J.M., Andersen M.E., Gargas M.L., Clewell H.J., Erickson R.J. A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish Toxicology and Applied Pharmacology. 1990;106(3):433-447.
Bradbury S., McKim J.M., Coats J.R. Physiological response of rainbow trout (Salmo gairdneri) to acute fenvalerate intoxication Pesticide Biochemistry and Physiology. 1987;27(3):275-288.
McKim J.M., Bradbury S.P., Niemi G.J. Fish acute toxicity syndromes and their use in the QSAR approach to hazard assessment Environmental Health Perspectives. 1987;Vol. 71:171-186.
McKim J.M., Schmieder P.K., Carlson R.W., Hunt E.P., Niemi G.J. Use of respiratory‐cardiovascular responses of rainbow trout (Salmo gairdneri) in identifying acute toxicity syndromes in fish: Part 1. pentachlorophenol, 2,4‐dinitrophenol, tricaine methanesulfonate and 1‐octanol Environmental Toxicology and Chemistry. 1987;6(4):295-312.
McKim J.M., Schmieder P.K., Niemi G.J., Carlson R.W., Henry T.R. Use of respiratory‐cardiovascular responses of rainbow trout (Salmo gairdneri) in identifying acute toxicity syndromes in fish: Part 2. malathion, carbaryl, acrolein and benzaldehyde Environmental Toxicology and Chemistry. 1987;6(4):313-328.
Bradbury S., Coats J., McKim J. Toxicokinetics of fenvalerate in rainbow trout (Salmo Gairdneri) Environmental Toxicology and Chemistry. 1986;5(6):567-576.
McKim J., Schmieder P., Erickson R. Toxicokinetic modeling of [<sup>14</sup>C]pentachlorophenol in the rainbow trout (Salmo gairdneri) Aquatic Toxicology. 1986;9(1):59-80.
Bradbury S., Coats J., McKim J. Differential toxicity and uptake of two fenvalerate formulations in fathead minnows Pimephales promelas Environmental Toxicology and Chemistry. 1985;4(4):533-541.
McKim J., Schmieder P., Veith G. Absorption dynamics of organic chemical transport across trout gills as related to octanol-water partition coefficient Toxicology and Applied Pharmacology. 1985;77(1):1-10.
McKim J., Heath E. Dose determinations for waterborne 2,5,2′,5′-[<sup>14</sup>C]tetrachlorobiphenyl and related pharmacokinetics in two species of trout (Salmo gairdneri and Salvelinus fontinalis): A mass-balance approach Toxicology and Applied Pharmacology. 1983;68(2):177-187.
McKim J.M., Goeden H. A direct measure of the uptake efficiency of a xenobiotic chemical across the gills of brook trout (Salvelinus fontinalis) under normoxic and hypoxic conditions Comparative Biochemistry and Physiology. Part C, Comparative. 1982;72(1):65-74.
McKim J.M., Syrett R. Mobile surgical table with automatic solenoid system for fishery applications Progressive Fish-Culturist. 1982;44(2):75-78.
Eaton J., McKim J., Holcombe G. Metal toxicity to embryos and larvae of seven freshwater fish species-i. cadmium Bulletin of Environmental Contamination and Toxicology. 1978;19(1):95-103.
McKim J., Eaton J., Holcombe G. Metal toxicity to embryos and larvae of eight species of freshwater fish-II: Copper Bulletin of Environmental Contamination and Toxicology. 1978;19(1):608-616.
McKim J., Anderson R., Benoit D., Spehar R., Stokes G. Effects of pollution on freshwater fish Journal of the Water Pollution Control Federation. 1976;48(6):1544-1620.
McKim J., Olson G., Holcombe G., Hunt E. Long term effects of methylmercuric chloride on three generations of brook trout (Salvelinus fontinalis): Toxicity, accumulation, distribution, and elimination J.FISH.RES.BOARD CANADA. 1976;33(12):2726-2739.
McKim J., Arthur J., Thorslund T. Toxicity of a linear alkylate sulfonate detergent to larvae of four species of freshwater fish Bulletin of Environmental Contamination and Toxicology. 1975;14(1):1-7.
McKim J., Benoit D., Biesinger K., Brungs W., Siefert R. Effects of pollution on freshwater fish. Journal of the Water Pollution Control Federation. 1975;47(6):1711-1768.
McKim J., Christensen G., Tucker J., Benoit D., Lewis M. Effects of pollution on freshwater fish Journal of the Water Pollution Control Federation. 1974;46(6):1540-1591.
McKim J., Cristensen G., Tucker J., Lewis M. Effects of pollution on freshwater fish Journal of the Water Pollution Control Federation. 1973;45(6):1370-1407.
Christensen G., McKim J., Brungs W., Hunt E. Changes in the blood of the brown bullhead (Ictalurus nebulosus (Lesueur)) following short and long term exposure to copper(II) Toxicology and Applied Pharmacology. 1972;23(3):417-427.