Eric D Achtyes, MD, MS, DFAPA

Eric D Achtyes, MD, MS, DFAPA photo

Eric D Achtyes, MD, MS, DFAPA

Chair, Department of Psychiatry

Professor, Department of Psychiatry

Contact Information

Patient Care Related:
Psychiatry, 269.337.6373

Biosketch

Eric D. Achtyes, MD, MS graduated from Calvin College and then earned a master’s degree in chemistry from the University of Washington in Seattle. He then completed medical school at the University of Michigan, his internship at the Michigan State University Kalamazoo Center for Medical Studies (MSU-KCMS) and his adult psychiatry residency training at the Massachusetts General Hospital/McLean/Harvard program where he served as chief resident on the addictions inpatient unit at McLean Hospital. He is Professor and Chair of Psychiatry at the Western Michigan University Homer Stryker M.D. School of Medicine where he teaches and mentors medical students and psychiatric residents. Dr. Achtyes has been an investigator on more than 65 clinical trials in depression and schizophrenia, including both industry and federally funded research projects from NIMH, NIDA, NIA, NICHD, NIAAA and CMS, and has authored more than 120 publications in peer-reviewed journals including the American Journal of Human Genetics, BMJ, BJP, JAMA, JAMA Psychiatry, Lancet Psychiatry, Molecular Psychiatry, Nature and Nature Medicine. He is currently an Associate Editor for the journal Frontiers in Psychiatry. He has served as the President of the Michigan Psychiatric Society, is a Distinguished Fellow of the American Psychiatric Association. In 2022 he was named ‘Physician/Psychiatrist of the Year’ by NAMI Michigan.

    • Residency 2007, Adult Psychiatry, Massachusetts General Hospital
    • Internship 2004, Transitional year, Michigan State University Kalamazoo Center for Medical Studies
    • MD 2003, University of Michigan-Ann Arbor
    • MS 1998, Chemistry, University of Washington-Seattle Campus
    • BS 1997, Chemistry, Calvin College
    • Schizophrenia
    • General Adult Psychiatry
    • Depression
    • Comparison of the Efficacy of Neuromodulation Therapies in Schizophrenia: A Systematic Review and Network Meta-analysis. Rajalingam, R., Dorrance, S., Khury, M., Hodgson, D., Patel, V., Kapoor, A., Sun, C., Lakshmi Nandakumar, A., Achtyes, E. , 2026 American Society of Clinical Psychopharmacology Annual Meeting, Miami, FL, 05/2026
    • Bringing Rigor to the Use of AI in Psychiatry: Potential Pitfalls and a Path Forward. Achtyes, E., Monteith, S., Torous, J., American Psychiatric Association Annual Meeting, San Francisco, CA, 05/2026
    • Multiple Mental Health Conditions Amplify Social Vulnerability in Public Defender Clients. Achtyes, E., Monroe, G., Reece, J., Samaraweera, N., Minkel, J., American Psychiatric Association Annual Meeting , San Francisco, CA, 05/2026
    • WMed Department of Psychiatry. Achtyes, E. , American Association of Chairs of Departments of Psychiatry Annual Meeting , San Francisco, CA, 05/2026
    • Lower Kynurenic Acid in the Temporal Pole of Suicide Decedents – Implications for Neurotransmission and Neuroprotection. Aleer, A., Anis, E., Sha, Q., Zameer, S., Isaguirre, C., Sheldon, RD., Rosoklija, G., Dwork, A., Underwood, M., Achtyes, E.D., Mann, J.J., Brundin, L., Society of Biological Psychiatry Annual Meeting, New York, NY, 05/2026
    • Plasma Lactate as a Metabolic Predictor of Ketamine Response in Treatment-Resistant Depression. Scaini, G., Gusmao, CTP., Tamez, MCC., Cordeiro, RC., de Quevedo, J., Tye, S., Elmallakh, R., Parikh, S., Bobo, W., Goes, FS., Vande Voort, JL., Nykamp, L, Singh, B., Nelson, E., Thase, M., Frye, M, Greden, J., Achtyes, E. , Society of Biological Psychiatry Annual Meeting, New York, NY, 05/2026
    • Modulation of GABA Synthesis by Intravenous Racemic Ketamine in Treatment-Resistant Major Depressive Disorder: Insights from the NNDC Bio-K Multicenter Trial. Sing, B., MahmoudianDehkordi, S., Fogaca, M.V., Vande Voort, J.L., Parikh, S.V., Achtyes, E.D., Goes, F.S., Scaini, G., Bobo, W.V., Greden, J.F., Frye, M.A., Kaddurah-Daouk, R., Society of Biological Psychiatry Annual Meeting, New York, NY, 05/2026
    • Associations Between Gut-derived Bacterial Metabolites, Inflammation, and Recent Suicide Attempt in Major Depressive Disorder. Forton, C., Sha, Q., Cave, T., Isaguirre, C., Sheldon, R., Youssef, N., Achtyes, E., Mann, J., Brundin, L., Society of Biological Psychiatry Annual Meeting, New York, NY, 05/2026
    • Bringing Rigor to the Use of AI in Psychiatry: Potential Pitfalls and a Path Forward. Achtyes, E., Department of Investigative Medicine at the Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, 04/2026
    • Comorbid Mental Health Problems Predict Greater Legal Burden in Clients of Public Defenders. Minkel, J., Reece, J., Pellegrin, L., Samaraweera, N., Roth, G., Karpus, J., Davenport, T., Standish, E., Achtyes, ED, Michigan Psychiatric Society Annual meeting, Livonia, MI, 04/2026
    • Lack of Social Supports in Psychiatric Outpatients: A Pilot Study. Cheng, T., Chala, F., Patel, D., Saini, K., Voytenko, V., Mayle, H., Achtyes, E., Michigan Psychiatric Society Annual meeting, Livonia, MI, 04/2026
    • Comparison of the Efficacy of Neuromodulation Therapies in Schizophrenia: A Systematic Review and Network Meta-analysis. Rajalingam, R., Dorrance, S., Khury, M., Hodgson, D., Patel, V., Kapoor, A., Sun, C., Lakshmi Nandakumar, A., Achtyes, E. , 44th Annual Kalamazoo Community and Health Services Research Day, Kalamazoo, MI, 04/2026
    • Lack of Social Supports in Psychiatric Outpatients: A Pilot Study. Cheng, T., Chala, F., Patel, D., Saini, K., Voytenko, V., Mayle, H., Achtyes, E., 44th Annual Kalamazoo Community and Health Services Research Day, Kalamazoo, MI, 04/2026
    • Interim analysis of an ongoing pragmatic trial of a digital therapeutic (CT-155/BI 3972080) aimed at improving negative symptoms of schizophrenia. Pratap, A., Gandhi, A., Zhu, Z., Hare, B., Cohen, E., Sodhi, P., Varma, A., Brenner, R., Ballon, J., Achtyes, E., Dorner-Ciossek, C., von der Goltz, C., Schizophrenia International Research Society (SIRS) meeting , Florence, Italy, 03/2026
    • Four Distinct Mental Health Profiles Predict Social Vulnerability in Public Defender Clients: A Latent Profile Analysis. Minkel, J., Monroe, G., Achtyes, E., Samaraweera, N., Pellegrin, L., Davenport, T., Reece, J., 2026 Annual Conference of the American Psychology-Law Society , Reno, NV, 03/2026
    • Metabolomic Signatures of Intravenous Racemic Ketamine in Treatment-Resistant Major Depressive Disorder: The Bio-K/NNDC Multicenter Trial. Singh, B., MahmoudianDehkordi, S., Vande Voort, J., Parikh, S., Achtyes, E., Goes, F., Bobo, W., Tye, S., Greden, J., Frye, M., Kaddurah-Daouk, R., 64th annual meeting of the American College of Neuropsychopharmacology, Nassau, Bahamas, 01/2026
    • Metabolomic Predictors of Ketamine Response in Treatment-Resistant Depression: The Role of Plasma Lactate. Scaini, G., Tamez, MCC., de Quevedo, J., Tye, S., Elmallakh, R., Parikh, S., Bobo, W., Goes, F., Vande Voort, J., Nykamp, L, Singh, B., Nelson, E., Thase, M., Frye, M, Greden, J., Achtyes, E., 64th annual meeting of the American College of Neuropsychopharmacology, Nassau, Bahamas, 01/2026
    • Personal Experiences of Social Isolation Among U.S. Family Medicine Providers and Their Impact on Clinical Practice. Mueller, F., Achtyes, E., Holman, H. , 101st meeting of the European General Practice Network, Plovdiv, Bulgaria, 10/2025
    • Personal Experience with Loneliness Shapes Teaching and Clinical Practice: A CERA Survey of Family Medicine Educators. Charara, A., Holman, H., Achtyes, E., Müller, F. , 2025 Society of Teachers of Family Medicine Annual Spring Conference , Salt Lake City, UT, 05/2025
    • Epigenetic Regulation and Prediction of Suicide Risk in Patients with Major Depressive Disorder. Sha, Q., Escobar Galvis, M., Smart, L., Kassien, J., Youssef, N., Achtyes, E., Mann, J., Brundin, L. , Society of Biological Psychiatry Annual Meeting, Toronto, Canada, 04/2025
    • Genome-Wide DNA Methylation Changes Related to Suicidal Behavior in Adults With Major Depressive Disorder and Overlap With Genes Linked to Childhood Trauma Exposure. Sha, Q., Achtyes, E., Escobar Galvis, M., Mann, J., Youssef, N. , Society of Biological Psychiatry Annual Meeting, Toronto, Canada, 04/2025
    • Increasing Cytomegalovirus Positivity in Postpartum is Linked to Reduced Depressive Symptoms. Anis, E., Smart, L., Keaton, S., Cave, T., Achtyes, E., Brundin, L. , Society of Biological Psychiatry Annual Meeting, Toronto, Canada, 04/2025
    • Lamotrigine co-administration may reduce effectiveness of intravenous ketamine in the treatment of major depressive episodes. El-Mallakh, R.S, Miozza, L., Parikh, S.V., Vande Voort, J.L., Yocum, A.K., Achtyes, E., Goes, F.S., Nykamp, L., Singh, B., Lopez-Vives, D., Sera, C.E., Maixner, D., Tarnal, V., Severe, J., Bartek, S. , 26th Annual Conference of the International Society for Bipolar Disorders , Reykjavik, Iceland, 10/2024
    • Mitigation of ketamine-benzodiazepine interaction in the treatment of major depressive episodes. Miozza, L., El-Mallakh, R.S, Parikh, S., Vande Voort, J., Yocum, A., Achtyes, E., Goes, F., Nykamp, L., Singh, B., Lopez, D., Sera, C., Maixner, D., Tarnal, V., Severe, J., Bartek, S. , 26th Annual Conference of the International Society for Bipolar Disorders , Reykjavik, Iceland, 09/2024
    • Herpes Simplex Reactivation Triggers Symptom Exacerbation in Patients with Major Depressive Disorder. Anis, E., Smart, L., Capan, C., Forton, C., Escobar Galvis, M.L., Sha, Q., Achtyes, E., Brundin, L. , 16th National Network of Depression Centers 2024 Annual Conference , Salt Lake City, UT, 09/2024
    • Controversies in Mental Health Care in the United States: Praxis, Technology, and Regulation. Achtyes, E., Gibb, T., Nagalla, M., Redinger, K., Redinger, M. , International Academy of Law and Mental Health international congress , Barcelona, Spain, 07/2024
    • Clinical Outcomes in the Biomarkers of Ketamine (Bio-K) Study of Open-Label IV Ketamine for Refractory Depression. Parikh SV, Vande Voort JL, Yocum A, Achtyes E, Goes FS, Nykamp L, Singh B, Lopez D, Maixner D, Tarnal V, Severe, J, Frye MA, Greden J, Bobo WV, Tye S. , the American Society of Clinical Psychopharmacology , Miami, FL, 05/2024
    • Elevated Plasma Anthranilic Acid-To-Intercellular Adhesion Molecule 1 (AA/ICAM1) Predicts Ketamine Response in Treatment-Resistant Depression (TRD). Murata S, Madaj Z, Elmallakh R, Parikh S, Bobo W, Goes F, Vande Voort J, Singh B, Meideros G, Nelson E, Frye M, Greden J, Achtyes E, Brundin L. , American Society of Clinical Psychopharmacology Annual Meeting, Miami, FL, 05/2024
    • Abnormal Oculomotor Corollary Discharge Signaling as a Trans-diagnostic Mechanism of Psychosis. Yao B, Rolfs M, Slate R, Roberts D, Fattal J, Achtyes ED, Tso IF, Diwadkar VA, Kashy D, Bao J, Thakkar KN. , Visual Sciences Society annual meeting , St. Pete Beach, FL, 05/2024
    • Treatment patterns and outcomes from OASIS: Observational Study of Long-Acting Injectables in Schizophrenia. Strand, L.N., Doane, M.J., Arevalo, C., McGrory, J.A., Weiden, P.J., Achtyes, E.D., Harvey, P.D., Kane, J.M., Saklad, S.R., Trotter, J., Velligan, D.I. , Academy of Managed Care Pharmacy Meeting, New Orleans, LA, 04/2024
    • Baseline Demographics and Clinical Characteristics From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, American Association of Psychiatric Pharmacists Annual Meeting , Orlando, FL, 04/2024
    • Treatment Patterns From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, American Association of Psychiatric Pharmacists Annual Meeting , Orlando, FL, 04/2024
    • Outcomes From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, American Association of Psychiatric Pharmacists Annual Meeting , Orlando, FL, 04/2024
    • Tardive Dyskinesia: Clinical Management and Considerations for Special Populations. Achtyes, E. , Alabama District Branch of the American Psychiatric Association Annual Meeting, virtual, virtual, 12/2023
    • Outcomes From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, NEI Congress, Colorado Springs, CO, 11/2023
    • Baseline Demographics and Clinical Characteristics From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, NEI Congress, Colorado Springs, CO, 11/2023
    • Treatment Patterns From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, NEI Congress, Colorado Springs, CO, 11/2023
    • Mitigation of Ketamine-Benzodiazepine Interaction in the Treatment of Major Depressive Episodes. Miozza, L., El-Mallakh, R., Parikh, S.V., Vande Voort, J.L., Yocum, A.K., Achtyes, E., Goes, F.S., Nykamp, L., Singh, B., Lopez-Vives, D., Sera, C., Maixner, D., Tarnal, V., Severe, J., Bartek, S., Tye, S.J., Rico, J., Stoppel, C.J., Beccera, A., Smart, L., Miller, C.R., Frye, M.A., Greden, J.F., Bobo, W.V. , 2023 National Network of Depression Centers Annual Conference, Houston, TX, 10/2023
    • Change in Neurocognitive Functioning in Patients with Treatment-Resistant Depression with Serial Intravenous Ketamine Infusions: The Bio-K Multicenter Trial. Singh, B., Parikh, S.V., Vande Voort, J.L., Pazdernick, V., Yocum, A.K., Achtyes, E., Goes, F.S., Greden, J.F., Bobo, W.V., Burdick, K., Frye, M.A., Ryan, K. , 2023 National Network of Depression Centers Annual Conference, Houston, TX, 10/2023
    • A Pathway to Putting Patients First: Spotlight on TAAR1 Agonists. Hoberg, A., Achtyes, E., Yeiser B. , American Psychiatric Nurses Association 36th Annual Conference, Orlando, FL, 10/2023
    • Porphyromonas Gingivalis K Serotype Seropositivity and Serointensity are Associated with Peripartum Depression. Joseph, J., Sha,Q., Achtyes, E., Wadwahan, A., Dagdag, A., Constantine, N.T., Makkar, H., Mohyuddin, I., Brenner, L.A., RachBeisel, J.A., Lowry,C., Hoisington, A., Spector, A.M., Hsu, K.L., Ernst, R.K., Leach, R., Brundin, L., Reynolds, M.A., Postolache, T.T. , 23rd WPA World Congress of Psychiatry, Vienna, Austria, 09/2023
    • Corollary Discharge Associated with Saccadic Eye Movements in Individuals with Schizophrenia and Bipolar Disorder with Psychotic Features. Roberts, D., Yao, B., Rolfs, M., Fattal, J., Bao, J., Achtyes, ED., Tso, IF., Thakkar, KN. , Society for Research in Psychopathology conference , St. Louis, MO, 09/2023
    • Wrap-Up and Resources. Achtyes, E. , 2nd Annual WMed Well-Being Promotion/Suicide Prevention Symposium, Kalamazoo, MI, 09/2023
    • Outcomes From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, 2023 US Psych Congress , Nashville, TN, 09/2023
    • Treatment Patterns From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, 2023 US Psych Congress , Nashville, TN, 09/2023
    • Baseline Demographics and Clinical Characteristics From OASIS: Observational Study of Long-Acting Injectable Antipsychotics in Schizophrenia. Strand LN, Doane M, Arevalo C, McGrory J, Weiden P, Achtyes ED, Harvey PD, Kane JM, Saklad SR, Trotter J, Velligan DI, 2023 US Psych Congress , Nashville, TN, 09/2023
    • Addressing the Challenge of Stepping Down from Coordinated Specialty Care (CSC) for First Episode Psychosis (FEP): the NAV2GO Model. Adams, C., Kempema, K., Palazzolo, S., Ellermets, A., VanDyke, L., Achtyes, E. , International Early Psychosis Association (IEPA) 14th International Conference on Early Intervention in Mental Health , Lausanne, Switzerland, 07/2023
    • Key Stakeholders’ Preferences on Policies Influencing the Availability of Psychiatric Electroceutical Interventions for Treatment-Resistant Depression. McCright, A., Achtyes, E., Bluhm, R., Cabrera, L. , NIH 9th Annual BRAIN Initiative Meeting , Washington DC, Washington DC, 06/2023
    • Expanding therapeutic options for schizophrenia: Considering patient preferences when developing novel long-acting injectable treatments. Achtyes, E., Procyshyn, R., Correll, C. , Schizophrenia International Research Society Annual Meeting, Toronto, Canada, 05/2023
    • Gender Differences in Biomarkers and the Effects of Cannabinoids in Psychotic Illnesses: A Review of the Literature. Shabdar S, Bradtke J, Gongolli J, Mills L, Tse J, Achtyes E, 41st Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
    • Gender differences in Biomarkers and the Effects of Cannabinoids in Psychotic Illnesses: a Review of the Literature. Shabdar, S., Bradtke, J., Gongolli, J., Mills, L., Tse, J., Achtyes, E. , 41st Annual Kalamazoo Community Medical & Health Sciences Research Day , Kalamazoo, MI, 05/2023
    • Gender Differences in Presentation, Outcome, Social Functioning, and Trauma Experiences in Psychotic Illnesses: A Review of the Literature. Gongolli J, Bradtke J, Shabdar S, Mills L, Tse J, Achtyes E, 41st Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
    • Gender differences in Presentation, Outcome, Social Functioning, and Trauma Experiences in Psychotic Illnesses: a Review of the Literature. Gongolli, J., Bradtke, J., Shabdar, S., Mills, L., Tse, J., Achtyes, E. , 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, MI, 05/2023
    • Immune Dysregulation and Perinatal Mental Illness. Achtyes, E., Gur, T., Gifford, J., Osborne, L. , 79th Society of Biological Psychiatry Annual Meeting, San Diego, CA, 04/2023
    • Translation and Validation of the PHQ-9 and GAD-7 in Kinyarwanda. Kube, M., Hansen, A., Achtyes, E., Holman, H., Muller, F. , Corewell Health Research Day, Grand Rapids, MI, 04/2023
    • A Pilot Study on the Relationship between Personality Pathology and TMS Outcomes. Huprich, S., Beauchamp, L., Achtyes, E., Sanders, W. , Michigan Psychiatric Society Annual Meeting , Grand Rapids, MI, 04/2023
    • Gender differences in treatment outcomes and social functioning in psychotic illnesses: a review of the literature. Bradtke, J., Shabdar, S., Tse, J., Gongolli, J., Mills, L., Achtyes, E. , Michigan Psychiatric Society Annual Meeting , Grand Rapids, MI, 04/2023
    • Gender differences in presentation, prodrome, and trauma experiences in psychotic illnesses: a review of the literature. Shabdar, S., Bradtke, J., Tse, J., Gongolli, J., Mills, L., Achtyes, E. , Michigan Psychiatric Society Annual Meeting , Grand Rapids, MI, 04/2023
    • Modern Electroconvulsive Therapy Stigma. Wilson, S., Sullivan, C., Cooper, D., Widge, A., Achtyes, E., Bluhm, R., McCright, A., Cabrera, L., Anxiety & Depression Association of America Conference , Washington DC, Washington DC, 04/2023
    • Observational Study of Long-Acting Injectables in Schizophrenia (OASIS): Baseline Patient Demographics and Clinical Characteristics of Early Enrollees. Gasper, S., O’Sullivan A.K., Haider, B., Keane, E., McGrory, J., Achtyes, E., Harvey, P.D., Kane, J., Saklad, S., Trotter, J., Velligan, D, Academy of Managed Care Pharmacy 2023 - 35th Annual Meeting & Expo , San Antonio, TX, 03/2023