Research Assistant Professor, Department of Biomedical Sciences
Biosketch
Benchang Guo, PhD, received his undergraduate degree at Anhui Normal University. He completed his PhD in Oncology at Shanghai Institute of Cell Biology, Chinese Academy of Science, and postdoctoral training in the Boston University Medical Center before accepting a faculty position at the Feinstein Institute for Medical Research. As a director of a laboratory focusing on B cell immunology and B cell-related diseases, Dr. Guo has been funded by the NIH and institution. He currently is the Assistant Professor for Western Michigan University Homer Stryker M.D. School of Medicine focusing on dysfunction of B cells in autoimmune disease, infectious disease, inflammation, and leukemia.
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Education and Training
- Doctorate 2001, Oncology, Shanghai Institute of Cell Biology, Chinese Academy of Science,
- MS 1997, Microbiology, Xiamen University
- BS 1994, Biology, Anhui Normal University
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Research
- Cellular Immunology
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Publications
Guo B., Ludlow A.V., Brightwell A.S., Rothstein T.L. Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice Cellular Immunology. 2019;346
Guo B., Rothstein T. RasGRP1 is an essential signaling molecule for development of B1a cells with autoantigen receptors Journal of Immunology. 2016;196:2583-2590.
Guo B., Zhang L., Chiorazzi N., Rothstein T.L. IL-4 rescues surface IgM expression in chronic lymphocytic leukemia Blood. 2016;128:553-562.
Husain-Krautter S., Kramer J.M., Li W., Guo B., Rothstein T.L. The osteopontin transgenic mouse is a new model for Sjögren's syndrome Clinical Immunology. 2015;157:30-42.
Guo B., Rothstein T. IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation Journal of Immunology. 2013;191:670-677.
Guo B., Rothstein T.L. A novel Lyn-protein kinase Cδ/ε-protein kinase D axis is activated in B cells by signalosome-independent alternate pathway BCR signaling European Journal of Immunology. 2013;43:1643-1650.
Guo B., Tumang J., Rothstein T. B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways Molecular Immunology. 2009;46:587-591.
Rothstein T., Guo B. Receptor crosstalk: Reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontin Journal of Internal Medicine. 2009;265:632-643.
Dye J.R., Palvanov A., Guo B., Rothstein T.L. B cell receptor cross-talk: Exposure to lipopolysaccharide induces an alternate pathway for B cell receptor-induced ERK phosphorylation and NF-κB activation Journal of Immunology. 2007;179:229-235.
Guo B., Blair D., Chiles T.C., Lowell C.A., Rothstein T.L. Cutting edge: B cell receptor (BCR) cross-talk: The IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to rottlerin, and depends on Lyn Journal of Immunology. 2007;178:4726-4730.
Guo B., Rothstein T. B Cell Receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent Journal of Immunology. 2005;174:5375-5381.